Seroatlas · Human Serome Atlas

HNRNPU

Heterogeneous nuclear ribonucleoprotein U

Also known as: C1orf199, FLJ30202, FLJ37978, HNRNPU-AS1, HNRPU, HNRPU_HUMAN, NCRNA00201, SAF-A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q00839
Gene
HNRNPU
Ensembl
ENSG00000153187
Chromosome
1
Canonical length
825 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. [provided by RefSeq, Jun 2017]

Canonical amino-acid sequenceUniProt

825 residues, UniProt reviewed canonical sequence.

>Q00839|HNRNPU
     1  MSSSPVNVKK LKVSELKEEL KKRRLSDKGL KAELMERLQA ALDDEEAGGR PAMEPGNGSL
    61  DLGGDSAGRS GAGLEQEAAA GGDEEEEEEE EEEEGISALD GDQMELGEEN GAAGAADSGP
   121  MEEEEAASED ENGDDQGFQE GEDELGDEEE GAGDENGHGE QQPQPPATQQ QQPQQQRGAA
   181  KEAAGKSSGP TSLFAVTVAP PGARQGQQQA GGKKKAEGGG GGGRPGAPAA GDGKTEQKGG
   241  DKKRGVKRPR EDHGRGYFEY IEENKYSRAK SPQPPVEEED EHFDDTVVCL DTYNCDLHFK
   301  ISRDRLSASS LTMESFAFLW AGGRASYGVS KGKVCFEMKV TEKIPVRHLY TKDIDIHEVR
   361  IGWSLTTSGM LLGEEEFSYG YSLKGIKTCN CETEDYGEKF DENDVITCFA NFESDEVELS
   421  YAKNGQDLGV AFKISKEVLA GRPLFPHVLC HNCAVEFNFG QKEKPYFPIP EEYTFIQNVP
   481  LEDRVRGPKG PEEKKDCEVV MMIGLPGAGK TTWVTKHAAE NPGKYNILGT NTIMDKMMVA
   541  GFKKQMADTG KLNTLLQRAP QCLGKFIEIA ARKKRNFILD QTNVSAAAQR RKMCLFAGFQ
   601  RKAVVVCPKD EDYKQRTQKK AEVEGKDLPE HAVLKMKGNF TLPEVAECFD EITYVELQKE
   661  EAQKLLEQYK EESKKALPPE KKQNTGSKKS NKNKSGKNQF NRGGGHRGRG GFNMRGGNFR
   721  GGAPGNRGGY NRRGNMPQRG GGGGGSGGIG YPYPRAPVFP GRGSYSNRGN YNRGGMPNRG
   781  NYNQNFRGRG NNRGYKNQSQ GYNQWQQGQF WGQKPWSQHY HQGYY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPU can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
169 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 169 nTPM
  • thymus: 131 nTPM
  • ovary: 126 nTPM
  • retina: 118 nTPM
  • cerebellum: 115 nTPM
  • epididymis: 114 nTPM

Single-cell type

  • late spermatids: 870 nCPM
  • monocyte progenitors: 841 nCPM
  • erythrocyte progenitors: 718 nCPM
  • megakaryocyte progenitors: 665 nCPM
  • neutrophil progenitors: 662 nCPM
  • neutrophils: 627 nCPM

Immune cell

  • plasmacytoid DC: 31 nTPM
  • naive CD4 T-cell: 26 nTPM
  • basophil: 23 nTPM
  • memory B-cell: 23 nTPM
  • memory CD4 T-cell: 22 nTPM
  • memory CD8 T-cell: 22 nTPM

Brain region

  • white matter: 156 nTPM
  • cerebral cortex: 133 nTPM
  • basal ganglia: 133 nTPM
  • spinal cord: 132 nTPM
  • cerebellum: 131 nTPM
  • thalamus: 127 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HNRNPU.

Disease | AllUniProt

Conditions HNRNPU is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 54 (DEE54) MIM:617391

Disease | GeneticClinVar

153 pathogenic / likely-pathogenic of 1,197 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.11
gnomAD pLI
1
gnomAD missense Z
3.37
DepMap mean gene effect
-1.09
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPU in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPU as an antibody target. Whether an autoantibody or antibody against HNRNPU could matter depends on whether native HNRNPU is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPU is annotated at the cell surface, where native HNRNPU is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HNRNPU as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HNRNPU. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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