Seroatlas · Human Serome Atlas

KIF2B

Kinesin-like protein KIF2B

Also known as: KIF2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N4N8
Gene
KIF2B
Ensembl
ENSG00000141200
Chromosome
17
Canonical length
673 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Microtubules,Cytokinetic bridge,Mitotic spindle,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in metaphase chromosome alignment; microtubule depolymerization; and regulation of chromosome segregation. Predicted to be located in cytosol. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>Q8N4N8|KIF2B
     1  MASQFCLPES PCLSPLKPLK PHFGDIQEGI YVAIQRSDKR IHLAVVTEIN RENYWVTVEW
    61  VEKAVKKGKK IDLETILLLN PALDSAEHPM PPPPLSPLAL APSSAIRDQR TATKWVAMIP
   121  QKNQTASGDS LDVRVPSKPC LMKQKKSPCL WEIQKLQEQR EKRRRLQQEI RARRALDVNT
   181  RNPNYEIMHM IEEYRRHLDS SKISVLEPPQ EHRICVCVRK RPLNQRETTL KDLDIITVPS
   241  DNVVMVHESK QKVDLTRYLQ NQTFCFDHAF DDKASNELVY QFTAQPLVES IFRKGMATCF
   301  AYGQTGSGKT YTMGGDFSGT AQDCSKGIYA LVAQDVFLLL RNSTYEKLDL KVYGTFFEIY
   361  GGKVYDLLNW KKKLQVLEDG NQQIQVVGLQ EKEVCCVEEV LNLVEIGNSC RTSRQTPVNA
   421  HSSRSHAVFQ IILKSGRIMH GKFSLVDLAG NERGADTTKA SRKRQLEGAE INKSLLALKE
   481  CILALGQNKP HTPFRASKLT LVLRDSFIGQ NSSTCMIATI SPGMTSCENT LNTLRYANRV
   541  KKLNVDVRPY HRGHYPIGHE APRMLKSHIG NSEMSLQRDE FIKIPYVQSE EQKEIEEVET
   601  LPTLLGKDTT ISGKGSSQWL ENIQERAGGV HHDIDFCIAR SLSILEQKID ALTEIQKKLK
   661  LLLADLHVKS KVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • testis: 71 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 817 nCPM
  • late spermatids: 765 nCPM
  • late primary spermatocytes: 240 nCPM
  • sertoli cells: 4.8 nCPM
  • leydig cells: 3.7 nCPM
  • undifferentiated spermatogonia: 1.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.7 nTPM
  • basal ganglia: 0.6 nTPM
  • white matter: 0.3 nTPM
  • medulla oblongata: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-0.71
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF2B as an antibody target. Whether an autoantibody or antibody against KIF2B could matter depends on whether native KIF2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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