Seroatlas · Human Serome Atlas

KIF11

Kinesin-like protein KIF11

Also known as: Eg5, HKSP, KIF11_HUMAN, KNSL1, TRIP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52732
Gene: KIF11
Ensembl: ENSG00000138160
Chromosome: 10
Canonical length: 1056 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Mitotic spindle,Basal body,Cytosol,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1056 residues, UniProt reviewed canonical sequence.

>P52732|KIF11
     1  MASQPNSSAK KKEEKGKNIQ VVVRCRPFNL AERKASAHSI VECDPVRKEV SVRTGGLADK
    61  SSRKTYTFDM VFGASTKQID VYRSVVCPIL DEVIMGYNCT IFAYGQTGTG KTFTMEGERS
   121  PNEEYTWEED PLAGIIPRTL HQIFEKLTDN GTEFSVKVSL LEIYNEELFD LLNPSSDVSE
   181  RLQMFDDPRN KRGVIIKGLE EITVHNKDEV YQILEKGAAK RTTAATLMNA YSSRSHSVFS
   241  VTIHMKETTI DGEELVKIGK LNLVDLAGSE NIGRSGAVDK RAREAGNINQ SLLTLGRVIT
   301  ALVERTPHVP YRESKLTRIL QDSLGGRTRT SIIATISPAS LNLEETLSTL EYAHRAKNIL
   361  NKPEVNQKLT KKALIKEYTE EIERLKRDLA AAREKNGVYI SEENFRVMSG KLTVQEEQIV
   421  ELIEKIGAVE EELNRVTELF MDNKNELDQC KSDLQNKTQE LETTQKHLQE TKLQLVKEEY
   481  ITSALESTEE KLHDAASKLL NTVEETTKDV SGLHSKLDRK KAVDQHNAEA QDIFGKNLNS
   541  LFNNMEELIK DGSSKQKAML EVHKTLFGNL LSSSVSALDT ITTVALGSLT SIPENVSTHV
   601  SQIFNMILKE QSLAAESKTV LQELINVLKT DLLSSLEMIL SPTVVSILKI NSQLKHIFKT
   661  SLTVADKIED QKKELDGFLS ILCNNLHELQ ENTICSLVES QKQCGNLTED LKTIKQTHSQ
   721  ELCKLMNLWT ERFCALEEKC ENIQKPLSSV QENIQQKSKD IVNKMTFHSQ KFCADSDGFS
   781  QELRNFNQEG TKLVEESVKH SDKLNGNLEK ISQETEQRCE SLNTRTVYFS EQWVSSLNER
   841  EQELHNLLEV VSQCCEASSS DITEKSDGRK AAHEKQHNIF LDQMTIDEDK LIAQNLELNE
   901  TIKIGLTKLN CFLEQDLKLD IPTGTTPQRK SYLYPSTLVR TEPREHLLDQ LKRKQPELLM
   961  MLNCSENNKE ETIPDVDVEE AVLGQYTEEP LSQEPSVDAG VDCSSIGGVP FFQHKKSHGK
  1021  DKENRGINTL ERSKVEETTE HLVTKSRLPL RAQINL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

thymus: 35 nTPM
bone marrow: 18 nTPM
tonsil: 17 nTPM
lymph node: 16 nTPM
testis: 11 nTPM
appendix: 8 nTPM

Single-cell type

monocyte progenitors: 257 nCPM
erythrocyte progenitors: 145 nCPM
neutrophil progenitors: 118 nCPM
megakaryocyte progenitors: 90 nCPM
early primary spermatocytes: 70 nCPM
differentiating spermatogonia: 37 nCPM

Immune cell

T-reg: 1.1 nTPM
NK-cell: 1 nTPM
basophil: 0.8 nTPM
memory B-cell: 0.6 nTPM
memory CD4 T-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM

Brain region

basal ganglia: 1.6 nTPM
medulla oblongata: 1.5 nTPM
midbrain: 1.5 nTPM
cerebral cortex: 1.4 nTPM
pons: 1.4 nTPM
white matter: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF11.

Disease | AllUniProt

Conditions KIF11 is implicated in, by any mechanism.

Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development (MCLMR) MIM:152950

Disease | GeneticClinVar

191 pathogenic / likely-pathogenic of 1,043 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
Retinal dystrophy
Inborn genetic diseases
KIF11-related disorder
Microcephaly

Disease | ImmuneIEDB

Conditions an epitope on KIF11 was assayed in.

systemic scleroderma B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 3.27
DepMap mean gene effect: -2.57
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Kinesin motor domain
Kinesin motor domain, conserved site
P-loop containing nucleoside triphosphate hydrolase
Kinesin motor domain superfamily
Kinesin-like protein KIF11-like
Kinesin motor domain
Kinesin-associated microtubule-binding domain
Kinesin-like protein KIF11-like, kinesin motor domain
Kinesin-associated microtubule-binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF11 as an antibody target. Whether an autoantibody or antibody against KIF11 could matter depends on whether native KIF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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