Seroatlas · Human Serome Atlas

KIFC3

Kinesin-like protein KIFC3

Also known as: KIFC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVG8
Gene: KIFC3
Ensembl: ENSG00000140859
Chromosome: 16
Canonical length: 833 aa
Protein class: Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

833 residues, UniProt reviewed canonical sequence.

>Q9BVG8|KIFC3
     1  MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT GPGRLRTGRG
    61  KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL YLTLQVEHLK EKLISQAQEV
   121  SRLRSELGGT DLEKHRDLLM VENERLRQEM RRCEAELQEL RTKPAGPCPG CEHSQESAQL
   181  RDKLSQLQLE MAESKGMLSE LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS
   241  HETIASLRAQ SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL
   301  QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA QVEMKAVHEN
   361  LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL RSVKAEIGQA IEEVNSNNQE
   421  LLRKYRRELQ LRKKCHNELV RLKGNIRVIA RVRPVTKEDG EGPEATNAVT FDADDDSIIH
   481  LLHKGKPVSF ELDKVFSPQA SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG
   541  TAENPGINQR ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP
   601  DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL LIVTVRGVDC
   661  STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS LSALGDVIAA LRSRQGHVPF
   721  RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK NTSETLYSLK FAERVRSVEL GPGLRRAELG
   781  SWSSQEHLEW EPACQTPQPS ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIFC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 168 nTPM

Expression across tissuesHPA

Tissue

kidney: 168 nTPM
liver: 77 nTPM
retina: 76 nTPM
pancreas: 68 nTPM
skin: 65 nTPM
testis: 61 nTPM

Single-cell type

rod photoreceptor cells: 1,050 nCPM
late spermatids: 639 nCPM
esophageal apical cells: 605 nCPM
cone photoreceptor cells: 594 nCPM
proximal tubule cells: 403 nCPM
enterocytes: 295 nCPM

Immune cell

gdT-cell: 1.5 nTPM
memory CD8 T-cell: 1.5 nTPM
memory B-cell: 0.7 nTPM
non-classical monocyte: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM
naive B-cell: 0.6 nTPM

Brain region

white matter: 317 nTPM
hypothalamus: 311 nTPM
thalamus: 309 nTPM
cerebral cortex: 299 nTPM
pons: 295 nTPM
cerebellum: 295 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.01
gnomAD missense Z: 1.99
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIFC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ABI2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIFC3 as an antibody target. Whether an autoantibody or antibody against KIFC3 could matter depends on whether native KIFC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIFC3 is annotated at the cell surface, where native KIFC3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIFC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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