Seroatlas · Human Serome Atlas

RAB9B

Ras-related protein Rab-9B

Also known as: RAB9B_HUMAN, RAB9L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP90
Gene: RAB9B
Ensembl: ENSG00000123570
Chromosome: X
Canonical length: 201 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q9NP90|RAB9B
     1  MSGKSLLLKV ILLGDGGVGK SSLMNRYVTN KFDSQAFHTI GVEFLNRDLE VDGRFVTLQI
    61  WDTAGQERFK SLRTPFYRGA DCCLLTFSVD DRQSFENLGN WQKEFIYYAD VKDPEHFPFV
   121  VLGNKVDKED RQVTTEEAQT WCMENGDYPY LETSAKDDTN VTVAFEEAVR QVLAVEEQLE
   181  HCMLGHTIDL NSGSKAGSSC C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 20 nTPM
cerebellum: 17 nTPM
basal ganglia: 9.9 nTPM
smooth muscle: 9.2 nTPM
hypothalamus: 9.1 nTPM
seminal vesicle: 8.9 nTPM

Single-cell type

podocytes: 3.1 nCPM
loop of henle epithelial cells: 1.1 nCPM
hematopoietic stem cells: 0.5 nCPM
proximal tubule cells: 0.5 nCPM
smooth muscle cells: 0.5 nCPM
vascular smooth muscle cells: 0.5 nCPM

Immune cell

NK-cell: 0.8 nTPM
memory B-cell: 0.5 nTPM
naive B-cell: 0.4 nTPM
eosinophil: 0.1 nTPM
myeloid DC: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

hypothalamus: 22 nTPM
cerebellum: 20 nTPM
cerebral cortex: 18 nTPM
pons: 18 nTPM
basal ganglia: 17 nTPM
hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.73
gnomAD missense Z: 1.8
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB9B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB9B as an antibody target. Whether an autoantibody or antibody against RAB9B could matter depends on whether native RAB9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB9B is annotated at the cell surface, where native RAB9B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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