Seroatlas · Human Serome Atlas

RAB1B

Ras-related protein Rab-1B

Also known as: RAB1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0U4
Gene: RAB1B
Ensembl: ENSG00000174903
Chromosome: 11
Canonical length: 201 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Golgi apparatus

OverviewNCBI Gene

Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q9H0U4|RAB1B
     1  MNPEYDYLFK LLLIGDSGVG KSCLLLRFAD DTYTESYIST IGVDFKIRTI ELDGKTIKLQ
    61  IWDTAGQERF RTITSSYYRG AHGIIVVYDV TDQESYANVK QWLQEIDRYA SENVNKLLVG
   121  NKSDLTTKKV VDNTTAKEFA DSLGIPFLET SAKNATNVEQ AFMTMAAEIK KRMGPGAASG
   181  GERPNLKIDS TPVKPAGGGC C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 242 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 242 nTPM
esophagus: 188 nTPM
blood vessel: 152 nTPM
heart muscle: 151 nTPM
skin: 151 nTPM
prostate: 144 nTPM

Single-cell type

platelets: 411 nCPM
esophageal apical cells: 213 nCPM
esophageal suprabasal cells: 128 nCPM
megakaryocytes: 118 nCPM
extravillous trophoblasts: 102 nCPM
colonocytes: 97 nCPM

Immune cell

neutrophil: 422 nTPM
total PBMC: 375 nTPM
eosinophil: 330 nTPM
non-classical monocyte: 245 nTPM
gdT-cell: 228 nTPM
intermediate monocyte: 212 nTPM

Brain region

thalamus: 137 nTPM
medulla oblongata: 132 nTPM
midbrain: 129 nTPM
amygdala: 128 nTPM
spinal cord: 125 nTPM
pons: 125 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.88
gnomAD missense Z: 1.74
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB1B as an antibody target. Whether an autoantibody or antibody against RAB1B could matter depends on whether native RAB1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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