Seroatlas · Human Serome Atlas

GIMAP6

GTPase IMAP family member 6

Also known as: FLJ22690, GIMA6_HUMAN, IAN6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P9H5
Gene: GIMAP6
Ensembl: ENSG00000133561
Chromosome: 7
Canonical length: 292 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of this gene may play a role in non-small cell lung cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is found in a cluster with seven additional GIMAP genes on the long arm of chromosome 7. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q6P9H5|GIMAP6
     1  MEEEEYEQIP QENPPEELSQ DPVLELSGGL REKEQKTPRR LRLILMGKTG SGKSATGNSI
    61  LGRDVFESKL STRPVTKTSQ RRSREWAGKE LEVIDTPNIL SPQVSPEVAD AICQAIVLSA
   121  PGPHAVLLVT QLGRFTDEDQ QVVRRLQEVF GVGVLGHTIL VFTRKEDLAG GSLEDYVRET
   181  NNQALAWLDV TLARRHCGFN NRAQGEEQEA QLRELMEKVE AIMWENEGDY YSNKAYQYTQ
   241  QNFRLKELQE RQVSQGQGSE DVPGEESWLE GLSQIQKESE EAHRCLLGKA DL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIMAP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

spleen: 60 nTPM
lymph node: 47 nTPM
adipose tissue: 39 nTPM
lung: 37 nTPM
tongue: 32 nTPM
appendix: 32 nTPM

Single-cell type

kupffer cells: 121 nCPM
vascular endothelial cells: 87 nCPM
hofbauer cells: 60 nCPM
lymphatic endothelial cells: 57 nCPM
nk-cells: 43 nCPM
innate lymphoid cells: 35 nCPM

Immune cell

NK-cell: 218 nTPM
total PBMC: 163 nTPM
MAIT T-cell: 127 nTPM
memory CD8 T-cell: 120 nTPM
gdT-cell: 113 nTPM
naive CD4 T-cell: 109 nTPM

Brain region

thalamus: 15 nTPM
medulla oblongata: 14 nTPM
pons: 14 nTPM
spinal cord: 14 nTPM
midbrain: 13 nTPM
white matter: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GIMAP6.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 70 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Primary Immune Deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.14
gnomAD missense Z: 0.29
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIMAP6 as an antibody target. Whether an autoantibody or antibody against GIMAP6 could matter depends on whether native GIMAP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIMAP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIMAP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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