Seroatlas · Human Serome Atlas

IQCA1L

IQ and AAA domain-containing protein 1-like

Also known as: IQCA1P1, IQCAL_HUMAN, TCAG_9762

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCM1
Gene: IQCA1L
Ensembl: ENSG00000278685
Chromosome: 7
Canonical length: 818 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Predicted to be involved in microtubule cytoskeleton organization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

818 residues, UniProt reviewed canonical sequence.

>A6NCM1|IQCA1L
     1  MSEGAYQRLW ESSHATLQEL LDQEQLLLEP APDRERQSFQ YRLASLYLHY LGLLRRFDTV
    61  YDQMVQPQKR RLLRRLLDGV AGRVLELKDE LVRADLCENH CLDRVLQDFK LTPADLEVPI
   121  PKYFLLEQST TVRERGLILA EILSRLEPVS SQKSFTGMHR TEAIILVQKA ERARQGRLRA
   181  TFMREIRRDE EQDGRIREDG WHKFSQGQAA VTIQKVWKGY LQRKRTQQDR RMEMEFIGML
   241  PSPNQVEHLS IISQPCLVED VQRLRQMEKE EEFRAAMVKA HDSLVETEGP DMKEKMKEQI
   301  RQWFIECHDL TGRFPDYPDA SSGGSYSIFA DKTPEQVRME LEMQMQENRK KEQEKSKEKG
   361  KDEKEKKKGK EEKAKKGEVD AVLQVLPSKC IPMICAGHEE YLNTWKNRCE SIHPSQNYDS
   421  ETLREEKRKE VELEIRIQVD ELMRQELRKL RLAVDKEEER PLRAPKKTPG KKTGKKKEKD
   481  LTSDRSVESL YEELVISGLL RKSESVALKD YIGDFLYLGS TLSLVKKLPM PSLFDIRQNV
   541  ALYAVLRLGS PDIHIMAPLI RSILLVGPSG MGKKMLVKAV CTETGANLFD LSPENLLGKY
   601  PGRNGAQMMV HIVFKVARLL QPSVIWIGNA EKNFYKKTPK EDKEMDPKRI KKDLTKALRL
   661  LTPGDRVMLI GTTSRPQLAE MRGLCRVYER ILFMPRPDYA SRYVLWKRMI EARGIQPTQH
   721  LDISALAKVS DGYTPGHILQ AIQSVLSERR FLQLSKRPLV ASEFLGQLVK LDPVYREEEE
   781  SLKDWYFKTP LGKKSMKHRM DQLEAEEAKL DKEKKKRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCA1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

testis: 4.1 nTPM
skeletal muscle: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 50 nCPM
late spermatids: 39 nCPM
early spermatids: 31 nCPM
parietal cells: 1.8 nCPM
myosatellite cells: 1.2 nCPM
epididymal basal cells: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.3 nTPM
cerebral cortex: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM

OntologyGO

Biological processes

microtubule severing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCA1L as an antibody target. Whether an autoantibody or antibody against IQCA1L could matter depends on whether native IQCA1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCA1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCA1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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