ABCC2

Protein identityUniProt · HPA

UniProt accession

Q92887

Gene

ABCC2

Ensembl

ENSG00000023839

Chromosome

10

Canonical length

1545 aa

Protein class

Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1545 residues, UniProt reviewed canonical sequence.

>Q92887|ABCC2
     1  MLEKFCNSTF WNSSFLDSPE ADLPLCFEQT VLVWIPLGYL WLLAPWQLLH VYKSRTKRSS
    61  TTKLYLAKQV FVGFLLILAA IELALVLTED SGQATVPAVR YTNPSLYLGT WLLVLLIQYS
   121  RQWCVQKNSW FLSLFWILSI LCGTFQFQTL IRTLLQGDNS NLAYSCLFFI SYGFQILILI
   181  FSAFSENNES SNNPSSIASF LSSITYSWYD SIILKGYKRP LTLEDVWEVD EEMKTKTLVS
   241  KFETHMKREL QKARRALQRR QEKSSQQNSG ARLPGLNKNQ SQSQDALVLE DVEKKKKKSG
   301  TKKDVPKSWL MKALFKTFYM VLLKSFLLKL VNDIFTFVSP QLLKLLISFA SDRDTYLWIG
   361  YLCAILLFTA ALIQSFCLQC YFQLCFKLGV KVRTAIMASV YKKALTLSNL ARKEYTVGET
   421  VNLMSVDAQK LMDVTNFMHM LWSSVLQIVL SIFFLWRELG PSVLAGVGVM VLVIPINAIL
   481  STKSKTIQVK NMKNKDKRLK IMNEILSGIK ILKYFAWEPS FRDQVQNLRK KELKNLLAFS
   541  QLQCVVIFVF QLTPVLVSVV TFSVYVLVDS NNILDAQKAF TSITLFNILR FPLSMLPMMI
   601  SSMLQASVST ERLEKYLGGD DLDTSAIRHD CNFDKAMQFS EASFTWEHDS EATVRDVNLD
   661  IMAGQLVAVI GPVGSGKSSL ISAMLGEMEN VHGHITIKGT TAYVPQQSWI QNGTIKDNIL
   721  FGTEFNEKRY QQVLEACALL PDLEMLPGGD LAEIGEKGIN LSGGQKQRIS LARATYQNLD
   781  IYLLDDPLSA VDAHVGKHIF NKVLGPNGLL KGKTRLLVTH SMHFLPQVDE IVVLGNGTIV
   841  EKGSYSALLA KKGEFAKNLK TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS
   901  ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK LIKKEFIETG
   961  KVKFSIYLEY LQAIGLFSIF FIILAFVMNS VAFIGSNLWL SAWTSDSKIF NSTDYPASQR
  1021  DMRVGVYGAL GLAQGIFVFI AHFWSAFGFV HASNILHKQL LNNILRAPMR FFDTTPTGRI
  1081  VNRFAGDIST VDDTLPQSLR SWITCFLGII STLVMICMAT PVFTIIVIPL GIIYVSVQMF
  1141  YVSTSRQLRR LDSVTRSPIY SHFSETVSGL PVIRAFEHQQ RFLKHNEVRI DTNQKCVFSW
  1201  ITSNRWLAIR LELVGNLTVF FSALMMVIYR DTLSGDTVGF VLSNALNITQ TLNWLVRMTS
  1261  EIETNIVAVE RITEYTKVEN EAPWVTDKRP PPDWPSKGKI QFNNYQVRYR PELDLVLRGI
  1321  TCDIGSMEKI GVVGRTGAGK SSLTNCLFRI LEAAGGQIII DGVDIASIGL HDLREKLTII
  1381  PQDPILFSGS LRMNLDPFNN YSDEEIWKAL ELAHLKSFVA SLQLGLSHEV TEAGGNLSIG
  1441  QRQLLCLGRA LLRKSKILVL DEATAAVDLE TDNLIQTTIQ NEFAHCTVIT IAHRLHTIMD
  1501  SDKVMVLDNG KIIECGSPEE LLQIPGPFYF MAKEAGIENV NSTKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

17

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

114 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ABCC2.

Disease | AllUniProt

Conditions ABCC2 is implicated in, by any mechanism.

• Dubin-Johnson syndrome (DJS) MIM:237500

Disease | GeneticClinVar

189 pathogenic / likely-pathogenic of 1,308 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Dubin-Johnson syndrome
• ABCC2-related disorder
• Inborn genetic diseases
• Autosomal recessive inherited pseudoxanthoma elasticum
• Colon adenocarcinoma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0

gnomAD missense Z

-0.99

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• bile acid and bile salt transport
• bilirubin transport
• cardiac muscle cell differentiation
• gene expression
• glutathione metabolic process
• glutathione transport
• heme catabolic process
• leukotriene transport
• mercury ion transport
• mRNA metabolic process
• negative regulation of gene expression
• phosphatidylinositol 3-kinase/protein kinase B signal transduction
• proximal tubule development
• response to cisplatin
• response to growth hormone
• response to insulin
• response to peptide
• response to wortmannin
• transepithelial transport
• transmembrane transport
• transport across blood-brain barrier
• xenobiotic detoxification by transmembrane export across the plasma membrane
• xenobiotic export from cell
• xenobiotic metabolic process
• xenobiotic transmembrane transport
• xenobiotic transport across blood-brain barrier
• glucuronoside transport

Molecular functions

• ABC-type glutathione S-conjugate transporter activity
• ABC-type transporter activity
• ABC-type xenobiotic transporter activity
• ATP binding
• ATP hydrolysis activity
• ATPase-coupled inorganic anion transmembrane transporter activity
• ATPase-coupled transmembrane transporter activity
• bilirubin transmembrane transporter activity
• organic anion transmembrane transporter activity
• toxin transmembrane transporter activity
• xenobiotic transmembrane transporter activity

Cellular components

• apical plasma membrane
• cell surface
• intercellular canaliculus
• plasma membrane
• vesicle

Protein domainsUniProt · Pfam · InterPro

• ABC transporter-like, ATP-binding domain
• AAA+ ATPase domain
• Multi drug resistance-associated protein
• ABC transporter type 1, transmembrane domain
• ABC transporter-like, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• ABC transporter type 1, transmembrane domain superfamily
• ATP-binding cassette transporter C-like
• ABC transporter, TMD0 domain
• ABC transporter
• ABC transporter transmembrane region
• ABC transporter TMD0 domain

KeywordsUniProt

• ATP-binding
• Cell membrane
• Glycoprotein
• Lipid transport
• Membrane
• Nucleotide-binding
• Phosphoprotein
• Repeat
• Translocase
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of ABCC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PDZK1
• NFKB1