Seroatlas · Human Serome Atlas

EIF4A3

Eukaryotic initiation factor 4A-III

Also known as: DDX48, EIF4AIII, Fal1, IF4A3_HUMAN, KIAA0111

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P38919
Gene
EIF4A3
Ensembl
ENSG00000141543
Chromosome
17
Canonical length
411 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>P38919|EIF4A3
     1  MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK
    61  PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSISVLQCL DIQVRETQAL ILAPTRELAV
   121  QIQKGLLALG DYMNVQCHAC IGGTNVGEDI RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA
   181  IKMLVLDEAD EMLNKGFKEQ IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL
   241  VKRDELTLEG IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA
   301  NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII NYDLPNNREL
   361  YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI DEMPMNVADL I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
176 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 176 nTPM
  • esophagus: 86 nTPM
  • urinary bladder: 78 nTPM
  • adrenal gland: 77 nTPM
  • thymus: 73 nTPM
  • tonsil: 70 nTPM

Single-cell type

  • pdcs: 421 nCPM
  • urothelial cells: 406 nCPM
  • esophageal apical cells: 350 nCPM
  • syncytiotrophoblasts: 342 nCPM
  • endometrial luminal cells: 340 nCPM
  • extravillous trophoblasts: 307 nCPM

Immune cell

  • plasmacytoid DC: 326 nTPM
  • total PBMC: 232 nTPM
  • myeloid DC: 200 nTPM
  • intermediate monocyte: 175 nTPM
  • classical monocyte: 167 nTPM
  • T-reg: 159 nTPM

Brain region

  • cerebral cortex: 37 nTPM
  • white matter: 32 nTPM
  • choroid plexus: 28 nTPM
  • spinal cord: 28 nTPM
  • hippocampal formation: 27 nTPM
  • cerebellum: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF4A3.

Disease | AllUniProt

Conditions EIF4A3 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 55 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Richieri Costa-Pereira syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.12
gnomAD pLI
1
gnomAD missense Z
4.02
DepMap mean gene effect
-2.29
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF4A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF4A3 as an antibody target. Whether an autoantibody or antibody against EIF4A3 could matter depends on whether native EIF4A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF4A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF4A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF4A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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