Seroatlas · Human Serome Atlas

AGAP9

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9

Also known as: AGAP9_HUMAN, bA301J7.2, CTGLF6, FLJ00312

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VTM2
Gene: AGAP9
Ensembl: ENSG00000204172
Chromosome: 10
Canonical length: 703 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activator activity and GTPase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

703 residues, UniProt reviewed canonical sequence.

>Q5VTM2|AGAP9
     1  MFEDVFSDSG NTGNFDRGKK RRLTIIECGC DINMMIDLAK VADLVLMLID ASFGFEMEMF
    61  EFLNICQAHG FPKILGVLTH LDSFKHNKQL KKTKKRLKHR FWTEVYQDKV GLTHELVQSL
   121  ISTYSTIDAK MASSRVTLLS NSKPLGSEAI DNQGVSLEFD QQQGSVCPSE SEIYEAGAED
   181  RMAGAPMAAA VQPAEVTVEV GEDLHMHQVR DREMPEVVEI RRSNCTNHCD LGDTSSYHTK
   241  VSTVHIMKKR NGGGSLNNYS SSIPPTPSTS QEDPQFSVPP TANTPTPVCK RSMRWSNLFT
   301  SEKGSDPDKE RKAPENHADT IGSGRAIPIK QGMLLKRSGK WLKTWKKKYV TLCSNGVLTY
   361  YSSLGDYMKN IHKKEIDLRT STIKVPGKWP SLATSACAPI SSSKSNGLSK DMDTGLGDSI
   421  CFSPGISSTT SPKLNPPPSP HANKKKHLKK KSTNNFMIVS ATGQTWHFEA TTYEERDAWV
   481  QAIQSQILAS LQSCKSSKSK SQLTSQSEAM ALQSIQNMRG NAHCVDCETQ NPKWASLNLG
   541  VLMCIECSGI HRSFGTRLSR VRSLELDDWP VELRKVMSSI GNELANSIWE GSSQGQTKPS
   601  IKSTREEKEW WIRSKYEEKL FLAPLPCTEL SLGQQLLRAT TDEDLQTAIL LLAHGSREEV
   661  NETCGEGDGC TALHLACRKG NVVLEQLLTG WTSWPEMPTG TQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGAP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

liver: 39 nTPM
pancreas: 31 nTPM
testis: 26 nTPM
pituitary gland: 25 nTPM
cerebellum: 23 nTPM
kidney: 23 nTPM

Single-cell type

early spermatids: 63 nCPM
proximal tubule cells: 51 nCPM
distal convoluted tubule cells: 46 nCPM
renal connecting tubule cells: 46 nCPM
podocytes: 42 nCPM
renal collecting duct principal cells: 35 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

white matter: 17 nTPM
cerebellum: 17 nTPM
choroid plexus: 17 nTPM
cerebral cortex: 16 nTPM
thalamus: 16 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.26
DepMap dependency class: selective

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGAP9 as an antibody target. Whether an autoantibody or antibody against AGAP9 could matter depends on whether native AGAP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGAP9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGAP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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