Seroatlas · Human Serome Atlas

MTREX

Exosome RNA helicase MTR4

Also known as: Dob1, fSAP118, KIAA0052, Mtr4, MTREX_HUMAN, SKIV2L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P42285
Gene: MTREX
Ensembl: ENSG00000039123
Chromosome: 5
Canonical length: 1042 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables ATP binding activity and RNA helicase activity. Involved in DNA damage response; RNA catabolic process; and maturation of 5.8S rRNA. Located in nuclear exosome (RNase complex) and nucleoplasm. Part of TRAMP complex and catalytic step 2 spliceosome. Biomarker of amyotrophic lateral sclerosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1042 residues, UniProt reviewed canonical sequence.

>P42285|MTREX
     1  MADAFGDELF SVFEGDSTTA AGTKKDKEKD KGKWKGPPGS ADKAGKRFDG KLQSESTNNG
    61  KNKRDVDFEG TDEPIFGKKP RIEESITEDL SLADLMPRVK VQSVETVEGC THEVALPAEE
   121  DYLPLKPRVG KAAKEYPFIL DAFQREAIQC VDNNQSVLVS AHTSAGKTVC AEYAIALALR
   181  EKQRVIFTSP IKALSNQKYR EMYEEFQDVG LMTGDVTINP TASCLVMTTE ILRSMLYRGS
   241  EVMREVAWVI FDEIHYMRDS ERGVVWEETI ILLPDNVHYV FLSATIPNAR QFAEWICHLH
   301  KQPCHVIYTD YRPTPLQHYI FPAGGDGLHL VVDENGDFRE DNFNTAMQVL RDAGDLAKGD
   361  QKGRKGGTKG PSNVFKIVKM IMERNFQPVI IFSFSKKDCE AYALQMTKLD FNTDEEKKMV
   421  EEVFSNAIDC LSDEDKKLPQ VEHVLPLLKR GIGIHHGGLL PILKETIEIL FSEGLIKALF
   481  ATETFAMGIN MPARTVLFTN ARKFDGKDFR WISSGEYIQM SGRAGRRGMD DRGIVILMVD
   541  EKMSPTIGKQ LLKGSADPLN SAFHLTYNMV LNLLRVEEIN PEYMLEKSFY QFQHYRAIPG
   601  VVEKVKNSEE QYNKIVIPNE ESVVIYYKIR QQLAKLGKEI EEYIHKPKYC LPFLQPGRLV
   661  KVKNEGDDFG WGVVVNFSKK SNVKPNSGEL DPLYVVEVLL RCSKESLKNS ATEAAKPAKP
   721  DEKGEMQVVP VLVHLLSAIS SVRLYIPKDL RPVDNRQSVL KSIQEVQKRF PDGIPLLDPI
   781  DDMGIQDQGL KKVIQKVEAF EHRMYSHPLH NDPNLETVYT LCEKKAQIAI DIKSAKRELK
   841  KARTVLQMDE LKCRKRVLRR LGFATSSDVI EMKGRVACEI SSADELLLTE MMFNGLFNDL
   901  SAEQATALLS CFVFQENSSE MPKLTEQLAG PLRQMQECAK RIAKVSAEAK LEIDEETYLS
   961  SFKPHLMDVV YTWATGATFA HICKMTDVFE GSIIRCMRRL EELLRQMCQA AKAIGNTELE
  1021  NKFAEGITKI KRDIVFAASL YL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTREX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 35 nTPM
blood vessel: 25 nTPM
parathyroid gland: 25 nTPM
lymph node: 24 nTPM
thyroid gland: 24 nTPM
duodenum: 23 nTPM

Single-cell type

myonuclei: 192 nCPM
lactotrophs: 180 nCPM
somatotrophs: 171 nCPM
thyrotrophs: 160 nCPM
adipocytes: 151 nCPM
fibro-adipogenic progenitors: 150 nCPM

Immune cell

non-classical monocyte: 8 nTPM
gdT-cell: 7.2 nTPM
MAIT T-cell: 6.9 nTPM
memory CD8 T-cell: 6.8 nTPM
plasmacytoid DC: 6.8 nTPM
myeloid DC: 6.4 nTPM

Brain region

cerebellum: 36 nTPM
choroid plexus: 30 nTPM
white matter: 30 nTPM
cerebral cortex: 25 nTPM
medulla oblongata: 24 nTPM
spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.86
DepMap mean gene effect: -1.63
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTREX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTREX as an antibody target. Whether an autoantibody or antibody against MTREX could matter depends on whether native MTREX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTREX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTREX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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