MYO7B

Protein identityUniProt · HPA

UniProt accession

Q6PIF6

Gene

MYO7B

Ensembl

ENSG00000169994

Chromosome

2

Canonical length

2116 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is found in brush border microvilli of epithelial cells in the intestines and kidneys. The encoded protein is involved in linking protocadherins to the actin cytoskeleton and is essential for proper microvilli function. This protein aids in the accumulation of intermicrovillar adhesion components such as harmonin and ANKS4B, and this accumulation is necessary for normal brush border action. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

2116 residues, UniProt reviewed canonical sequence.

>Q6PIF6|MYO7B
     1  MSGFRLGDHV WLEPPSTHKT GVAIGGIIKE AKPGKVLVED DEGKEHWIRA EDFGVLSPMH
    61  PNSVQGVDDM IRLGDLNEAG MVHNLLIRYQ QHKIYTYTGS ILVAVNPFQV LPLYTLEQVQ
   121  LYYSRHMGEL PPHVFAIANN CYFSMKRNKR DQCCIISGES GAGKTETTKL ILQFLATISG
   181  QHSWIEQQVL EANPILEAFG NAKTIRNDNS SRFGKYIDIY FNPSGVIEGA RIEQFLLEKS
   241  RVCRQAPEER NYHIFYCMLM GVSAEDKQLL SLGTPSEYHY LTMGNCTSCE GLNDAKDYAH
   301  IRSAMKILQF SDSESWDVIK LLAAILHLGN VGFMASVFEN LDASDVMETP AFPTVMKLLE
   361  VQHQELRDCL IKHTILIRGE FVTRSLNIAQ AADRRDAFVK GIYGHLFLWI VKKINAAIFT
   421  PPAQDPKNVR RAIGLLDIFG FENFENNSFE QLCINFANEH LQQFFVQHVF TMEQEEYRSE
   481  NISWDYIHYT DNRPTLDLLA LKPMSIISLL DEESRFPQGT DLTMLQKLNS VHANNKAFLQ
   541  PKNIHDARFG IAHFAGEVYY QAEGFLEKNR DVLSTDILTL VYSSKNKFLR EIFNLELAET
   601  KLGHGTIRQA KAGNHLFKSA DSNKRPSTLG SQFKQSLDQL MKILTNCQPY FIRCIKPNEY
   661  KKPLLFDREL CLRQLRYSGM METVHIRKSG FPIRYTFEEF SQRFGVLLPN AMRMQLQGKL
   721  RQMTLGITDV WLRTDKDWKA GKTKIFLRDH QDTLLEVQRS QVLDRAALSI QKVLRGYRYR
   781  KEFLRQRRAA VTLQAWWRGY CNRRNFKLIL VGFERLQAIA RSQPLARQYQ AMRQRTVQLQ
   841  ALCRGYLVRQ QVQAKRRAVV VIQAHARGMA ARRNFQQRKA NAPLVIPAEG QKSQGALPAK
   901  KRRSIYDTVT DTEMVEKVFG FLPAMIGGQE GQASPHFEDL ESKTQKLLEV DLDTVPMAEE
   961  PEEDVDGLAE YTFPKFAVTY FQKSASHTHI RRPLRYPLLY HEDDTDCLAA LVIWNVILRF
  1021  MGDLPEPVLY ARSSQQGSSV MRQIHDTLGR EHGAQVPQHS RSAQVASQLN IGEEALEPDG
  1081  LGADRPMSNL EKVHFIVGYA ILRPSLRDEI YCQICKQLSE NFKTSSLARG WILLSLCLGC
  1141  FPPSERFMKY LLNFIGQGPA TYGPFCAERL RRTYANGVRA EPPTWLELQA VKSKKHIPIQ
  1201  VILATGESLT VPVDSASTSR EMCMHIAHKQ GLSDHLGFSL QVAVYDKFWS LGSGRDHMMD
  1261  AIARCEQMAQ ERGESQRQSP WRIYFRKEFF TPWHDSREDP VSTELIYRQV LRGVWSGEYS
  1321  FEKEEELVEL LARHCYVQLG ASAESKAVQE LLPSCIPHKL YRTKPPDRWA SLVTAACAKA
  1381  PYTQKQVTPL AVREQVVDAA RLQWPLLFSR LFEVITLSGP RLPKTQLILA VNWKGLCFLD
  1441  QQEKMLLELS FPEVMGLATN REAQGGQRLL LSTMHEEYEF VSPSSVAIAE LVALFLEGLK
  1501  ERSIFAMALQ DRKATDDTTL LAFKKGDLLV LTKKQGLLAS ENWTLGQNDR TGKTGLVPMA
  1561  CLYTIPTVTK PSAQLLSLLA MSPEKRKLAA QEGQFTEPRP EEPPKEKLHT LEEFSYEFFR
  1621  APEKDMVSMA VLPLARARGH LWAYSCEPLR QPLLKRVHAN VDLWDIACQI FVAILRYMGD
  1681  YPSRQAWPTL ELTDQIFTLA LQHPALQDEV YCQILKQLTH NSNRHSEERG WQLLWLCTGL
  1741  FPPSKGLLPH AQKFIDTRRG KLLAPDCSRR IQKVLRTGPR KQPPHQVEVE AAEQNVSRIC
  1801  HKIYFPNDTS EMLEVVANTR VRDVCDSIAT RLQLASWEGC SLFIKISDKV ISQKEGDFFF
  1861  DSLREVSDWV KKNKPQKEGA PVTLPYQVYF MRKLWLNISP GKDVNADTIL HYHQELPKYL
  1921  RGFHKCSRED AIHLAGLIYK AQFNNDRSQL ASVPKILREL VPENLTRLMS SEEWKKSILL
  1981  AYDKHKDKTV EEAKVAFLKW ICRWPTFGSA FFEVKQTSEP SYPDVILIAI NRHGVLLIHP
  2041  KTKDLLTTYP FTKISSWSSG STYFHMALGS LGRGSRLLCE TSLGYKMDDL LTSYVQQLLS
  2101  AMNKQRGSKA PALAST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

74 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.73

gnomAD pLI

0

gnomAD missense Z

0.48

DepMap mean gene effect

-0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament organization
• actin filament-based movement
• brush border assembly
• cell differentiation
• endocytosis
• sensory organ development
• sensory perception of sound

Molecular functions

• actin filament binding
• ATP binding
• microfilament motor activity

Cellular components

• actin cytoskeleton
• apical cytoplasm
• brush border
• cytoplasm
• membrane
• microvillus
• myosin complex

Protein domainsUniProt · Pfam · InterPro

• IQ motif, EF-hand binding site
• FERM domain
• MyTH4 domain
• SH3 domain
• Myosin head, motor domain-like
• PH-like domain superfamily
• FERM/acyl-CoA-binding protein superfamily
• FERM central domain
• Band 4.1 domain
• P-loop containing nucleoside triphosphate hydrolase
• Ubiquitin-like domain superfamily
• FERM superfamily, second domain
• SH3-like domain superfamily
• Class VII myosin, motor domain
• Kinesin motor domain superfamily
• MyTH4 domain superfamily
• Myosin VII, FERM domain C-lobe, repeat 1
• Myosin VII, FERM domain C-lobe, repeat 2
• Unconventional Myosin ATPase
• Myosin VII, N-terminal domain
• Myosin head (motor domain)
• FERM central domain
• IQ calmodulin-binding motif
• MyTH4 domain
• Variant SH3 domain
• RA like domain
• Myosin-X FERM PH domain-like
• Myosin VII N-terminal beta barrel domain

KeywordsUniProt

• Actin-binding
• ATP-binding
• Cell projection
• Cytoplasm
• Cytoskeleton
• Differentiation
• Motor protein
• Myosin
• Nucleotide-binding
• Phosphoprotein
• Repeat
• SH3 domain

InteractionsUniProt · HPA

Protein binding partners of MYO7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANKS4B
• CALML4
• CDHR2
• CDHR5
• USH1C