Seroatlas · Human Serome Atlas

RAD51D

DNA repair protein RAD51 homolog 4

Also known as: HsTRAD, R51H3, RA51D_HUMAN, RAD51L3, Trad

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75771
Gene
RAD51D
Ensembl
ENSG00000185379
Chromosome
17
Canonical length
328 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>O75771|RAD51D
     1  MGVLRVGLCP GLTEEMIQLL RSHRIKTVVD LVSADLEEVA QKCGLSYKAL VALRRVLLAQ
    61  FSAFPVNGAD LYEELKTSTA ILSTGIGSLD KLLDAGLYTG EVTEIVGGPG SGKTQVCLCM
   121  AANVAHGLQQ NVLYVDSNGG LTASRLLQLL QAKTQDEEEQ AEALRRIQVV HAFDIFQMLD
   181  VLQELRGTVA QQVTGSSGTV KVVVVDSVTA VVSPLLGGQQ REGLALMMQL ARELKTLARD
   241  LGMAVVVTNH ITRDRDSGRL KPALGRSWSF VPSTRILLDT IEGAGASGGR RMACLAKSSR
   301  QPTGFQEMVD IGTWGTSEQS ATLQGDQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAD51D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
7.3 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 7.3 nTPM
  • basal ganglia: 6.7 nTPM
  • cerebral cortex: 6.6 nTPM
  • ovary: 6.3 nTPM
  • spleen: 6.2 nTPM
  • cervix: 5.9 nTPM

Single-cell type

  • late spermatids: 169 nCPM
  • early spermatids: 52 nCPM
  • megakaryocytes: 6.2 nCPM
  • late primary spermatocytes: 3.7 nCPM
  • medullary thymic epithelial cells: 2.4 nCPM
  • hematopoietic stem cells: 1.5 nCPM

Immune cell

  • NK-cell: 9.2 nTPM
  • gdT-cell: 8 nTPM
  • memory B-cell: 7.2 nTPM
  • memory CD8 T-cell: 7.1 nTPM
  • naive B-cell: 6.8 nTPM
  • plasmacytoid DC: 6.6 nTPM

Brain region

  • cerebral cortex: 11 nTPM
  • hypothalamus: 11 nTPM
  • white matter: 11 nTPM
  • midbrain: 11 nTPM
  • medulla oblongata: 10 nTPM
  • basal ganglia: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAD51D.

Disease | AllUniProt

Conditions RAD51D is implicated in, by any mechanism.

  • Breast-ovarian cancer, familial, 4 (BROVCA4) MIM:614291

Disease | GeneticClinVar

256 pathogenic / likely-pathogenic of 2,070 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
-0.11
DepMap mean gene effect
-0.55
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAD51D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAD51D as an antibody target. Whether an autoantibody or antibody against RAD51D could matter depends on whether native RAD51D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAD51D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAD51D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAD51D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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