Seroatlas · Human Serome Atlas

RHOJ

Rho-related GTP-binding protein RhoJ

Also known as: ARHJ, FLJ14445, RASL7B, RHOJ_HUMAN, TCL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4E5
Gene: RHOJ
Ensembl: ENSG00000126785
Chromosome: 14
Canonical length: 214 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Plasma membrane

OverviewNCBI Gene

This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q9H4E5|RHOJ
     1  MNCKEGTDSS CGCRGNDEKK MLKCVVVGDG AVGKTCLLMS YANDAFPEEY VPTVFDHYAV
    61  TVTVGGKQHL LGLYDTAGQE DYNQLRPLSY PNTDVFLICF SVVNPASYHN VQEEWVPELK
   121  DCMPHVPYVL IGTQIDLRDD PKTLARLLYM KEKPLTYEHG VKLAKAIGAQ CYLECSALTQ
   181  KGLKAVFDEA ILTIFHPKKK KKRCSEGHSC CSII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 29 nTPM
endometrium: 26 nTPM
gallbladder: 24 nTPM
lung: 20 nTPM
ovary: 19 nTPM
adipose tissue: 18 nTPM

Single-cell type

lymphatic endothelial cells: 643 nCPM
bergmann glia: 328 nCPM
vascular endothelial cells: 236 nCPM
astrocytes: 199 nCPM
fibro-adipogenic progenitors: 133 nCPM
myosatellite cells: 112 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

cerebral cortex: 25 nTPM
basal ganglia: 22 nTPM
thalamus: 21 nTPM
hippocampal formation: 20 nTPM
white matter: 18 nTPM
amygdala: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.01
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOJ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOJ as an antibody target. Whether an autoantibody or antibody against RHOJ could matter depends on whether native RHOJ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOJ is annotated at the cell surface, where native RHOJ is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOJ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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