MYO15B

Protein identityUniProt · HPA

UniProt accession

Q96JP2

Gene

MYO15B

Canonical length

3096 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MYO15B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

3096 residues, UniProt reviewed canonical sequence.

>Q96JP2|MYO15B
     1  MGRNQRKAPQ RLERPGRPAS GEQESGSASA DGAPSRERRS DRGQADRAKP AAEPATAGGQ
    61  GTPGGRRKPT AEGNGGCRRP GAGLSPKAQE RQSNAQRQGR GPRGGRGGRL EEGSLSGGEE
   121  LGGRRRRKRK DKGPSARRGR RTPRSLNGDT SGGDGGSSCP DSETREAQES GSQRGTAREL
   181  RPTPEPTDMG SEGTKTGPES ALEPSSDGLD SDWPHADTRG REGSSGTGPL GASEHSGGDS
   241  DSSPLGTGPG RGSRAAMASR TFEDSSRAPR DTGPAKDASD NRAQRGAEPE TMQASTARAP
   301  RHQVGKAVGQ VPAAAGEGEA GAAAGAGPED PAPLAALLVV RRLLARPPPG AASQAVGPRR
   361  AGLKERLLSV ARALGLLRWL RRRLRLRRRP PEGEGQGTGP RASEGWGRRK PDEGRGHGRG
   421  SKGRGRGKAD EGRGHERGDE GRGRGKADEG RGHERGYEGR GCGKADEGRG HERGDEGRDH
   481  QRGYEGWGRE PGLRHRLALR LAGLAGLGGM PRASPGGRSP QVPTSPVPGD PFDQEDETPD
   541  PKFAVVFPRI HRAGRASSSR SSEEASADAP TGEGRGWPRA GVGGHSEGCR TSGEGVSGLR
   601  RGSLLAPTAP DGPSLDESGS SSEAELETLN DEPPVRWAQG SGPHEGPRLG AAVLLPRLSL
   661  ETRLQQEGDP GLRGSLRELW EPEDEDEAVL ERDLELSLRP GLEAPPFPGA KGRSLGDGLE
   721  DMEDLARLRL VCDSSVLLCL KKRFHLGRIY TFGGPVLLVL NPHRSLPLFS PEVQASYHPR
   781  KALSTTPHIF AIVASAYDLA QNTGQDPCIL LCSSHCSGHS GSGKTEAAKK IMQFLSSLEQ
   841  DQTGNRECQV EDMLPILSSF GHAKTILNAN ASRFGQVFCL YLQQGVIVGA SVSHYLLETS
   901  RVVFQAQAER SFHVFYKLLA GLDSIERERL SLQGPETYYY LNQGQACRLQ GKEDAQDFEG
   961  LLKALQGLGL CPEELNAVWA VLAAILQLGN ICFSSSERES QEVAAVSSWA EIHTAARLLR
  1021  VPPECLEGAV TRRVTETPYG QVSRSLPVES AFDARDALAK ALYSRLFHRL LRRTNARLAP
  1081  PGEGGSIGTV TVVDAYGFEA LRVNGLEQLC NNLASERLQL FSSQMLLAQE EEECRRELLS
  1141  WVPVPQPPRE SCLDLLVDQP HSLLSILDAQ TWLSQATDHT FLQKSHYHHG DHPSYAKPRL
  1201  PLPVFTVRHY AGTVTYQVHK FLNRNRDQLD PAVVEMLGQS QLQLVGSLFQ EAEPQSRGGR
  1261  GRPTLASRFQ QALEDLIARL GRSHVYFIQC LTPNPGKLPG LFDVGHVTEQ LHQAAILEAV
  1321  GTRSANFPVR VPFEAFLASF QALGSEGQED LSDREKCGAV LSQVLGAESP LYHLGATKVL
  1381  LQEQGWQRLE ELRDQQRSQA LVDLHRSFHT CISRQRVLPR MQARMRGFQA RKRYLRRRAA
  1441  LGQLNTILLV AQPLLQRRQR LQLGRWQGWH SSERALERVP SMELGRLEIP AELAVMLKTA
  1501  ESHRDALAGS ITECLPPEVP ARPSLTLPAD IDLFPFSSFV AIGFQEPSLP RPGQPLAKPL
  1561  TQLDGDNPQR ALDINKVMLR LLGDGSLESW QRQIMGAYLV RQGQCRPGLR NELFSQLVAQ
  1621  LWQNPDEQQS QRGWALMAVL LSAFPPLPVL QKPLLKFVSD QAPRGMAALC QHKLLGALEQ
  1681  SQLASGATRA HPPTQLEWLA GWRRGRMALD VFTFSEECYS AEVESWTTGE QLAGWILQSR
  1741  GLEAPPRGWS VSLHSRDAWQ DLAGCDFVLD LISQTEDLGD PARPRSYPIT PLGSAEAIPL
  1801  APGIQAPSLP PGPPPGPAPT LPSRDHTGEV QRSGSLDGFL DQIFQPVISS GLSDLEQSWA
  1861  LSSRMKGGGA IGPTQQGYPM VYPGMIQMPA YQPGMVPAPM PMMPAMGTVP AMPAMVVPPQ
  1921  PPLPSLDAGQ LAVQQQNFIQ QQALILAQQM TAQAMSLSLE QQMQQRQQQA RASEAASQAS
  1981  PSAVTSKPRK PPTPPEKPQR DLGSEGGCLR ETSEEAEDRP YQPKSFQQKR NYFQRMGQPQ
  2041  ITVRTMKPPA KVHIPQGEAQ EEEEEEEEEE EQEEQEVETR AVPSPPPPPI VKKPLKQGGA
  2101  KAPKEAEAEP AKETAAKGHG QGPAQGRGTV VRSSDSKPKR PQPSREIGNI IRMYQSRPGP
  2161  VPVPVQPSRP PKAFLRKIDP KDEALAKLGI NGAHSSPPML SPSPGKGPPP AVAPRPKAPL
  2221  QLGPSSSIKE KQGPLLDLFG QKLPIAHTPP PPPAPPLPLP EDPGTLSAER RCLTQPVEDQ
  2281  GVSTQLLAPS GSVCFSYTGT PWKLFLRKEV FYPRENFSHP YYLRLLCEQI LRDTFSESCI
  2341  RISQNERRKM KDLLGGLEVD LDSLTTTEDS VKKRIVVAAR DNWANYFSRF FPVSGESGSD
  2401  VQLLAVSHRG LRLLKVTQGP GLRPDQLKIL CSYSFAEVLG VECRGGSTLE LSLKSEQLVL
  2461  HTARARAIEA LVELFLNELK KDSGYVIALR SYITDNCSLL SFHRGDLIKL LPVATLEPGW
  2521  QFGSAGGRSG LFPADIVQPA AAPDFSFSKE QRSGWHKGQL SNGEPGLARW DRASERPAHP
  2581  WSQAHSDDSE ATSLSSVAYA FLPDSHSYTM QEFARRYFRR SQALLGQTDG GAAGKDTDSL
  2641  VQYTKAPIQE SLLSLSDDVS KLAVASFLAL MRFMGDQSKP RGKDEMDLLY ELLKLCQQEK
  2701  LRDEIYCQVI KQVTGHPRPE HCTRGWSFLS LLTGFFPPST RLMPYLTKFL QDSGPSQELA
  2761  RSSQEHLQRT VKYGGRRRMP PPGEMKAFLK GQAIRLLLIH LPGGVDYRTN IQTFTVAAEV
  2821  QEELCRQMGI TEPQEVQEFA LFLIKEKSQL VRPLQPAEYL NSVVVDQDVS LHSRRLHWET
  2881  PLHFDNSTYI STHYSQVLWD YLQGKLPVSA KADAQLARLA ALQHLSKANR NTPSGQDLLA
  2941  YVPKQLQRQV NTASIKNLMG QELRRLEGHS PQEAQISFIE AMSQLPLFGY TVYGVLRVSM
  3001  QALSGPTLLG LNRQHLILMD PSSQSLYCRI ALKSLQRLHL LSPLEEKGPP GLEVNYGSAD
  3061  NPQTIWFELP QAQELLYTTV FLIDSSASCT EWPSIN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO15B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

202 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.06

gnomAD pLI

0

gnomAD missense Z

0.52

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• actin binding
• ATP binding
• cytoskeletal motor activity

Cellular components

• brush border
• cytoplasm
• myosin complex

Protein domainsUniProt · Pfam · InterPro

• FERM domain
• MyTH4 domain
• SH3 domain
• Myosin head, motor domain-like
• PH-like domain superfamily
• FERM/acyl-CoA-binding protein superfamily
• FERM central domain
• Band 4.1 domain
• P-loop containing nucleoside triphosphate hydrolase
• FERM superfamily, second domain
• SH3-like domain superfamily
• Kinesin motor domain superfamily
• MyTH4 domain superfamily
• Myosin-XV, FERM domain C-lobe
• Unconventional Myosin ATPase
• Unconventional myosin-XV-like domain
• Myosin head (motor domain)
• FERM central domain
• MyTH4 domain
• Variant SH3 domain
• Unconventional myosin-XV-like domain
• MYO15B, SH3 domain

KeywordsUniProt

• Actin-binding
• ATP-binding
• Cytoplasm
• Motor protein
• Myosin
• Nucleotide-binding
• Repeat
• SH3 domain