MRAS

Protein identityUniProt · HPA

UniProt accession

O14807

Gene

MRAS

Ensembl

ENSG00000158186

Chromosome

3

Canonical length

208 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins

Subcellular location

Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>O14807|MRAS
     1  MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW
    61  AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF EHVDRFHQLI LRVKDRESFP
   121  MILVANKVDL MHLRKITREQ GKEMATKHNI PYIETSAKDP PLNVDKAFHD LVRVIRQQIP
   181  EKSQKKKKKT KWRGDRATGT HKLQCVIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRAS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

113 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRAS.

Disease | AllUniProt

Conditions MRAS is implicated in, by any mechanism.

• Noonan syndrome 11 (NS11) MIM:618499

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 264 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• RASopathy
• Noonan syndrome 11
• Male infertility with azoospermia or oligozoospermia due to single gene mutation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.92

gnomAD missense Z

2.33

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin cytoskeleton organization
• cellular response to leukemia inhibitory factor
• Ras protein signal transduction

Molecular functions

• G protein activity
• GDP binding
• GTP binding
• GTP-dependent protein binding
• GTPase activity

Cellular components

• plasma membrane
• protein phosphatase type 1 complex

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTP-binding domain
• Small GTPase, Ras-type
• P-loop containing nucleoside triphosphate hydrolase
• Ras family

KeywordsUniProt

• Cell membrane
• GTP-binding
• Hydrolase
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Prenylation

InteractionsUniProt · HPA

Protein binding partners of MRAS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RGL3
• RASSF5