Seroatlas · Human Serome Atlas

GTPBP4

GTP-binding protein 4

Also known as: CRFG, FLJ10686, FLJ10690, GTPB4_HUMAN, NGB, NOG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZE4
Gene: GTPBP4
Ensembl: ENSG00000107937
Chromosome: 10
Canonical length: 634 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Nucleoli,Nucleoli rim

OverviewNCBI Gene

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>Q9BZE4|GTPBP4
     1  MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK VKFTQQNYHD
    61  RLSQILTDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN IAKNLVDNVA KDYVRLMKYG
   121  DSLYRCKQLK RAALGRMCTV IKRQKQSLEY LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG
   181  KSSFINKVTR ADVDVQPYAF TTKSLFVGHM DYKYLRWQVV DTPGILDHPL EDRNTIEMQA
   241  ITALAHLRAA VLYVMDLSEQ CGHGLREQLE LFQNIRPLFI NKPLIVVANK CDVKRIAELS
   301  EDDQKIFTDL QSEGFPVIET STLTEEGVIK VKTEACDRLL AHRVETKMKG NKVNEVLNRL
   361  HLAIPTRRDD KERPPFIPEG VVARRKRMET EESRKKRERD LELEMGDDYI LDLQKYWDLM
   421  NLSEKHDKIP EIWEGHNIAD YIDPAIMKKL EELEKEEELR TAAGEYDSVS ESEDEEMLEI
   481  RQLAKQIREK KKLKILESKE KNTQGPRMPR TAKKVQRTVL EKEMRSLGVD MDDKDDAHYA
   541  VQARRSRSIT RKRKREDSAP PSSVARSGSC SRTPRDVSGL RDVKMVKKAK TMMKNAQKKM
   601  NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTPBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 28 nTPM
bone marrow: 25 nTPM
adrenal gland: 21 nTPM
testis: 20 nTPM
urinary bladder: 17 nTPM
adipose tissue: 15 nTPM

Single-cell type

syncytiotrophoblasts: 131 nCPM
differentiating spermatogonia: 127 nCPM
urothelial cells: 126 nCPM
esophageal basal cells: 105 nCPM
endometrial glandular cells: 102 nCPM
erythrocyte progenitors: 99 nCPM

Immune cell

NK-cell: 19 nTPM
basophil: 18 nTPM
T-reg: 17 nTPM
intermediate monocyte: 16 nTPM
MAIT T-cell: 14 nTPM
non-classical monocyte: 13 nTPM

Brain region

white matter: 15 nTPM
spinal cord: 14 nTPM
hypothalamus: 14 nTPM
midbrain: 14 nTPM
choroid plexus: 14 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 0.08
DepMap mean gene effect: -1.72
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small GTP-binding domain
GTP binding domain
P-loop containing nucleoside triphosphate hydrolase
OBG-type guanine nucleotide-binding (G) domain
Nucleolar GTP-binding protein 1, Rossman-fold domain
NOG, C-terminal
Nucleolar GTP-binding protein 1
NOG1, N-terminal helical domain
Nucleolar GTP-binding protein 1 (NOG1)
NOGCT (NUC087) domain
NOG1 N-terminal helical domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GTPBP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTPBP4 as an antibody target. Whether an autoantibody or antibody against GTPBP4 could matter depends on whether native GTPBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTPBP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTPBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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