ADCY10

Protein identityUniProt · HPA

UniProt accession

Q96PN6

Gene

ADCY10

Ensembl

ENSG00000143199

Chromosome

1

Canonical length

1610 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

1610 residues, UniProt reviewed canonical sequence.

>Q96PN6|ADCY10
     1  MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG FTAMTEKFSS
    61  AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA LLALWRVERK QLKNIITVVI
   121  KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG HISMLVFGDE THSHFLVIGQ AVDDVRLAQN
   181  MAQMNDVILS PNCWQLCDRS MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY
   241  PSGEHKNLLR LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM
   301  FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF PGEKVPDELT
   361  HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV RHEYTVIGQK VNLAARMMMY
   421  YPGIVTCDSV TYNGSNLPAY FFKELPKKVM KGVADSGPLY QYWGRTEKVM FGMACLICNR
   481  KEDYPLLGRN KEINYFMYTM KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI
   541  IAISLNKISF HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF
   601  HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD STSWRFMEKL
   661  IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV QPNDISNKIC LDLNVSCISK
   721  ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL VFQQTESEEK TNRTWNNLFK YSIKLTEKLN
   781  MVTLHSDKES EEVCHLTSGV RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF
   841  TTELLFEILP CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK
   901  PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH LKCARFLEED
   961  AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG FKTEEKLILS NSEIPETSAF
  1021  FPENRSPEEI REKILNFFDH VLTKMKTSDE DIIPLESCQC EEILEIVILP LAHHFLALGE
  1081  NDKALYYFLE IASAYLIFCD NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV
  1141  CFNMGQIVLA KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK
  1201  RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ IIKAYLDYSL
  1261  YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE TLVFNKLIMG HLDLAIELGS
  1321  RALQMWALLQ NPNRHYQSLC RLSRCLLLNS RYPQLIQVLG RLWELSVTQE HIFSKAFFYF
  1381  VCLDILLYSG FVYRTFEECL EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY
  1441  KFSNRAKNLL PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV
  1501  AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK CWLNMNKESW
  1561  YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL MRANTVDNHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADCY10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

16 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADCY10.

Disease | AllUniProt

Conditions ADCY10 is implicated in, by any mechanism.

• Hypercalciuria absorptive 2 (HCA2) MIM:143870

Disease | GeneticClinVar

34 pathogenic / likely-pathogenic of 693 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Familial idiopathic hypercalciuria
• Reduced sperm motility
• Abnormal sperm morphology
• ADCY10-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.03

gnomAD pLI

0

gnomAD missense Z

0.46

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• cAMP biosynthetic process
• epithelial cilium movement involved in extracellular fluid movement
• glucose catabolic process
• intracellular signal transduction
• mitochondrial ATP transmembrane transport
• negative regulation of mitochondrial membrane potential
• negative regulation of reactive oxygen species biosynthetic process
• neuron projection extension
• neuron projection maintenance
• neuron projection retraction
• positive regulation of ATP biosynthetic process
• positive regulation of axon extension
• positive regulation of cardiac muscle cell apoptotic process
• positive regulation of cardiac muscle hypertrophy
• positive regulation of glycogen catabolic process
• positive regulation of mitochondrial depolarization
• positive regulation of ossification
• positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
• positive regulation of protein targeting to mitochondrion
• positive regulation of reactive oxygen species biosynthetic process
• positive regulation of vascular associated smooth muscle cell apoptotic process
• regulation of membrane repolarization
• regulation of mitophagy
• spermatid development
• negative regulation of cardiac muscle cell contraction

Molecular functions

• adenylate cyclase activity
• ATP binding
• ATPase binding
• magnesium ion binding
• manganese ion binding
• bicarbonate binding

Cellular components

• apical part of cell
• astrocyte end-foot
• basal part of cell
• central region of growth cone
• cilium
• cytoplasm
• cytoskeleton
• cytosol
• dendrite
• extracellular region
• mitochondrion
• neuronal cell body
• nucleus
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Adenylyl cyclase class-3/4/guanylyl cyclase
• P-loop containing nucleoside triphosphate hydrolase
• Nucleotide cyclase
• Adenylate and Guanylate cyclase catalytic domain
• Adenylate cyclase, type 10

KeywordsUniProt

• ATP-binding
• cAMP biosynthesis
• Cell membrane
• Cell projection
• Cytoplasm
• Cytoskeleton
• Lyase
• Magnesium
• Manganese
• Membrane
• Metal-binding
• Mitochondrion
• Nucleotide-binding
• Nucleus
• Repeat