NUBP2

Protein identityUniProt · HPA

UniProt accession

Q9Y5Y2

Gene

NUBP2

Ensembl

ENSG00000095906

Chromosome

16

Canonical length

271 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q9Y5Y2|NUBP2
     1  MEAAAEPGNL AGVRHIILVL SGKGGVGKST ISTELALALR HAGKKVGILD VDLCGPSIPR
    61  MLGAQGRAVH QCDRGWAPVF LDREQSISLM SVGFLLEKPD EAVVWRGPKK NALIKQFVSD
   121  VAWGELDYLV VDTPPGTSDE HMATIEALRP YQPLGALVVT TPQAVSVGDV RRELTFCRKT
   181  GLRVMGIVEN MSGFTCPHCT ECTSVFSRGG GEELAQLAGV PFLGSVPLDP ALMRTLEEGH
   241  DFIQEFPGSP AFAALTSIAQ KILDATPACL P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

57 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.2

gnomAD pLI

0

gnomAD missense Z

-0.07

DepMap mean gene effect

-0.62

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell projection organization
• iron-sulfur cluster assembly

Molecular functions

• 4 iron, 4 sulfur cluster binding
• ATP binding
• ATP-dependent FeS chaperone activity
• iron-sulfur cluster binding
• metal ion binding
• nucleotide binding

Cellular components

• axoneme
• centriole
• cytosol
• nucleoplasm
• spindle pole centrosome

Protein domainsUniProt · Pfam · InterPro

• Iron-sulfur cluster carrier protein-like, conserved site
• Mrp/NBP35 ATP-binding protein
• P-loop containing nucleoside triphosphate hydrolase
• Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
• NUBPL iron-transfer P-loop NTPase
• Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes

KeywordsUniProt

• 4Fe-4S
• Acetylation
• ATP-binding
• Cell projection
• Cilium
• Cilium biogenesis/degradation
• Cytoplasm
• Cytoskeleton
• Iron
• Iron-sulfur
• Metal-binding
• Nucleotide-binding
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of NUBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KIFC1
• NUBP1