RALB

Protein identityUniProt · HPA

UniProt accession

P11234

Gene

RALB

Ensembl

ENSG00000144118

Chromosome

2

Canonical length

206 aa

Protein class

Enzymes, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>P11234|RALB
     1  MAANKSKGQS SLALHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS YRKKVVLDGE
    61  EVQIDILDTA GQEDYAAIRD NYFRSGEGFL LVFSITEHES FTATAEFREQ ILRVKAEEDK
   121  IPLLVVGNKS DLEERRQVPV EEARSKAEEW GVQYVETSAK TRANVDKVFF DLMREIRTKK
   181  MSENKDKNGK KSSKNKKSFK ERCCLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RALB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

316 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.02

gnomAD pLI

0.02

gnomAD missense Z

1.86

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• cell division
• positive regulation of autophagosome assembly
• positive regulation of epidermal growth factor receptor signaling pathway
• positive regulation of innate immune response
• Ras protein signal transduction
• receptor internalization
• regulation of exocyst localization
• signal transduction
• regulation of exocyst assembly

Molecular functions

• ATPase binding
• G protein activity
• GDP binding
• GTP binding
• GTPase activity
• ubiquitin protein ligase binding

Cellular components

• extracellular exosome
• midbody
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTP-binding domain
• Small GTPase, Ras-type
• P-loop containing nucleoside triphosphate hydrolase
• Ras family

KeywordsUniProt

• Apoptosis
• Cell cycle
• Cell division
• Cell membrane
• GTP-binding
• Hydrolase
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Prenylation

InteractionsUniProt · HPA

Protein binding partners of RALB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EXOC2
• EXOC8
• RALBP1