Seroatlas · Human Serome Atlas

DDX55

ATP-dependent RNA helicase DDX55

Also known as: DDX55_HUMAN, KIAA1595

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHQ9
Gene: DDX55
Ensembl: ENSG00000111364
Chromosome: 12
Canonical length: 600 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

600 residues, UniProt reviewed canonical sequence.

>Q8NHQ9|DDX55
     1  MEHVTEGSWE SLPVPLHPQV LGALRELGFP YMTPVQSATI PLFMRNKDVA AEAVTGSGKT
    61  LAFVIPILEI LLRREEKLKK SQVGAIIITP TRELAIQIDE VLSHFTKHFP EFSQILWIGG
   121  RNPGEDVERF KQQGGNIIVA TPGRLEDMFR RKAEGLDLAS CVRSLDVLVL DEADRLLDMG
   181  FEASINTILE FLPKQRRTGL FSATQTQEVE NLVRAGLRNP VRVSVKEKGV AASSAQKTPS
   241  RLENYYMVCK ADEKFNQLVH FLRNHKQEKH LVFFSTCACV EYYGKALEVL VKGVKIMCIH
   301  GKMKYKRNKI FMEFRKLQSG ILVCTDVMAR GIDIPEVNWV LQYDPPSNAS AFVHRCGRTA
   361  RIGHGGSALV FLLPMEESYI NFLAINQKCP LQEMKPQRNT ADLLPKLKSM ALADRAVFEK
   421  GMKAFVSYVQ AYAKHECNLI FRLKDLDFAS LARGFALLRM PKMPELRGKQ FPDFVPVDVN
   481  TDTIPFKDKI REKQRQKLLE QQRREKTENE GRRKFIKNKA WSKQKAKKEK KKKMNEKRKR
   541  EEGSDIEDED MEELLNDTRL LKKLKKGKIT EEEFEKGLLT TGKRTIKTVD LGISDLEDDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 19 nTPM
pancreas: 15 nTPM
cerebellum: 15 nTPM
liver: 14 nTPM
spleen: 14 nTPM
skin: 13 nTPM

Single-cell type

late spermatids: 108 nCPM
early spermatids: 59 nCPM
erythrocyte progenitors: 47 nCPM
thyrotrophs: 45 nCPM
corticotrophs: 37 nCPM
lactotrophs: 36 nCPM

Immune cell

naive CD4 T-cell: 15 nTPM
memory B-cell: 14 nTPM
naive CD8 T-cell: 14 nTPM
NK-cell: 13 nTPM
plasmacytoid DC: 13 nTPM
MAIT T-cell: 12 nTPM

Brain region

cerebellum: 17 nTPM
white matter: 16 nTPM
pons: 14 nTPM
medulla oblongata: 14 nTPM
choroid plexus: 14 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -1.01
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maturation of LSU-rRNA

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX55 as an antibody target. Whether an autoantibody or antibody against DDX55 could matter depends on whether native DDX55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX55 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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