Seroatlas · Human Serome Atlas

RAB9A

Ras-related protein Rab-9A

Also known as: RAB9, RAB9A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51151
Gene: RAB9A
Ensembl: ENSG00000123595
Chromosome: X
Canonical length: 201 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables G protein activity; GDP binding activity; and GTP binding activity. Involved in positive regulation of exocytosis; receptor-mediated endocytosis; and regulation of protein localization. Located in late endosome; lysosome; and phagocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>P51151|RAB9A
     1  MAGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE VDGHFVTMQI
    61  WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN WKKEFIYYAD VKEPESFPFV
   121  ILGNKIDISE RQVSTEEAQA WCRDNGDYPY FETSAKDATN VAAAFEEAVR RVLATEDRSD
   181  HLIQTDTVNL HRKPKPSSSC C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB9A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 53 nTPM
adrenal gland: 49 nTPM
spinal cord: 37 nTPM
parathyroid gland: 36 nTPM
skin: 35 nTPM
salivary gland: 35 nTPM

Single-cell type

syncytiotrophoblasts: 503 nCPM
esophageal apical cells: 296 nCPM
urothelial cells: 173 nCPM
endometrial glandular cells: 168 nCPM
pancreatic duct cells: 166 nCPM
ocular epithelial cells: 135 nCPM

Immune cell

gdT-cell: 38 nTPM
classical monocyte: 38 nTPM
basophil: 34 nTPM
memory CD8 T-cell: 32 nTPM
NK-cell: 31 nTPM
MAIT T-cell: 30 nTPM

Brain region

white matter: 37 nTPM
medulla oblongata: 30 nTPM
spinal cord: 30 nTPM
cerebellum: 30 nTPM
basal ganglia: 27 nTPM
hypothalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.83
gnomAD missense Z: 1.28
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB9A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB9A as an antibody target. Whether an autoantibody or antibody against RAB9A could matter depends on whether native RAB9A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB9A is annotated at the cell surface, where native RAB9A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB9A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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