Seroatlas · Human Serome Atlas

CHST5

Carbohydrate sulfotransferase 5

Also known as: CHST5_HUMAN, FLJ22167, I-GLCNAC-6-ST

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZS9
Gene: CHST5
Ensembl: ENSG00000135702
Chromosome: 16
Canonical length: 411 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q9GZS9|CHST5
     1  MGMRARVPKV AHSTRRPPAA RMWLPRFSSK TVTVLLLAQT TCLLLFIISR PGPSSPAGGE
    61  DRVHVLVLSS WRSGSSFLGQ LFSQHPDVFY LMEPAWHVWT TLSQGSAATL HMAVRDLMRS
   121  IFLCDMDVFD AYMPQSRNLS AFFNWATSRA LCSPPACSAF PRGTISKQDV CKTLCTRQPF
   181  SLAREACRSY SHVVLKEVRF FNLQVLYPLL SDPALNLRIV HLVRDPRAVL RSREAAGPIL
   241  ARDNGIVLGT NGKWVEADPH LRLIREVCRS HVRIAEAATL KPPPFLRGRY RLVRFEDLAR
   301  EPLAEIRALY AFTGLTLTPQ LEAWIHNITH GSGIGKPIEA FHTSSRNARN VSQAWRHALP
   361  FTKILRVQEV CAGALQLLGY RPVYSADQQR DLTLDLVLPR GPDHFSWASP D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHST5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

duodenum: 82 nTPM
small intestine: 73 nTPM
rectum: 46 nTPM
colon: 43 nTPM
skeletal muscle: 6.5 nTPM
stomach: 4.3 nTPM

Single-cell type

colonocytes: 27 nCPM
enterocytes: 27 nCPM
goblet cells: 25 nCPM
ependymal cells: 14 nCPM
enteric transient amplifying cells: 11 nCPM
neuroendocrine cells: 8.5 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.3 nTPM
non-classical monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

choroid plexus: 8.6 nTPM
cerebral cortex: 8 nTPM
hippocampal formation: 8 nTPM
medulla oblongata: 7.8 nTPM
amygdala: 7.7 nTPM
basal ganglia: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHST5 as an antibody target. Whether an autoantibody or antibody against CHST5 could matter depends on whether native CHST5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHST5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHST5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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