Seroatlas · Human Serome Atlas

FIGNL2

Fidgetin-like protein 2

Also known as: FIGL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMB9
Gene: FIGNL2
Ensembl: ENSG00000261308
Chromosome: 12
Canonical length: 653 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Involved in microtubule severing and negative regulation of cell migration. Located in cell leading edge. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>A6NMB9|FIGNL2
     1  MHWTPEHAQP LNQWPEQHLD VSSTTPSPAH KLELPPGGRQ RCHYAWAHDD ISALTASNLL
    61  KRYAEKYSGV LDSPYERPAL GGYSDASFLN GAKGDPEPWP GPEPPYPLAS LHEGLPGTKS
   121  GGGGGSGALG GSPVLAGNLP EPLYAGNACG GPSAAPEYAA GYGGGYLAPG YCAQTGAALP
   181  PPPPAALLQP PPPPGYGPSA PLYNYPAGGY AAQPGYGALP PPPGPPPAPY LTPGLPAPTP
   241  LPAPAPPTAY GFPTAAPGAE SGLSLKRKAA DEGPEGRYRK YAYEPAKAPV ADGASYPAAD
   301  NGECRGNGFR AKPPGAAEEA SGKYGGGVPL KVLGSPVYGP QLEPFEKFPE RAPAPRGGFA
   361  VPSGETPKGV DPGALELVTS KMVDCGPPVQ WADVAGQGAL KAALEEELVW PLLRPPAYPG
   421  SLRPPRTVLL FGPRGAGKAL LGRCLATQLG ATLLRLRGAT LAAPGAAEGA RLLQAAFAAA
   481  RCRPPSVLLI SELEALLPAR DDGAAAGGAL QVPLLACLDG GCGAGADGVL VVGTTSRPAA
   541  LDEATRRRFS LRFYVALPDS PARGQILQRA LAQQGCALSE RELAALVQGT QGFSGGELGQ
   601  LCQQAAAGAG LPGLQRPLSY KDLEAALAKV GPRASAKELD SFVEWDKMYG SGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FIGNL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

kidney: 3.6 nTPM
parathyroid gland: 2.1 nTPM
cerebellum: 2 nTPM
pituitary gland: 1.4 nTPM
liver: 1 nTPM
basal ganglia: 0.7 nTPM

Single-cell type

proximal tubule cells: 43 nCPM
loop of henle epithelial cells: 26 nCPM
late spermatids: 19 nCPM
müller glia: 11 nCPM
lymphatic endothelial cells: 10 nCPM
cone photoreceptor cells: 8.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 4 nTPM
cerebral cortex: 3.6 nTPM
hypothalamus: 3.6 nTPM
basal ganglia: 3.3 nTPM
hippocampal formation: 3.2 nTPM
medulla oblongata: 3.2 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FIGNL2 as an antibody target. Whether an autoantibody or antibody against FIGNL2 could matter depends on whether native FIGNL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FIGNL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FIGNL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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