NLRC5

Protein identityUniProt · HPA

UniProt accession

Q86WI3

Gene

NLRC5

Ensembl

ENSG00000140853

Chromosome

16

Canonical length

1866 aa

Protein class

Predicted intracellular proteins

Subcellular location

Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

1866 residues, UniProt reviewed canonical sequence.

>Q86WI3|NLRC5
     1  MDPVGLQLGN KNLWSCLVRL LTKDPEWLNA KMKFFLPNTD LDSRNETLDP EQRVILQLNK
    61  LHVQGSDTWQ SFIHCVCMQL EVPLDLEVLL LSTFGYDDGF TSQLGAEGKS QPESQLHHGL
   121  KRPHQSCGSS PRRKQCKKQQ LELAKKYLQL LRTSAQQRYR SQIPGSGQPH AFHQVYVPPI
   181  LRRATASLDT PEGAIMGDVK VEDGADVSIS DLFNTRVNKG PRVTVLLGKA GMGKTTLAHR
   241  LCQKWAEGHL NCFQALFLFE FRQLNLITRF LTPSELLFDL YLSPESDHDT VFQYLEKNAD
   301  QVLLIFDGLD EALQPMGPDG PGPVLTLFSH LCNGTLLPGC RVMATSRPGK LPACLPAEAA
   361  MVHMLGFDGP RVEEYVNHFF SAQPSREGAL VELQTNGRLR SLCAVPALCQ VACLCLHHLL
   421  PDHAPGQSVA LLPNMTQLYM QMVLALSPPG HLPTSSLLDL GEVALRGLET GKVIFYAKDI
   481  APPLIAFGAT HSLLTSFCVC TGPGHQQTGY AFTHLSLQEF LAALHLMASP KVNKDTLTQY
   541  VTLHSRWVQR TKARLGLSDH LPTFLAGLAS CTCRPFLSHL AQGNEDCVGA KQAAVVQVLK
   601  KLATRKLTGP KVVELCHCVD ETQEPELASL TAQSLPYQLP FHNFPLTCTD LATLTNILEH
   661  REAPIHLDFD GCPLEPHCPE ALVGCGQIEN LSFKSRKCGD AFAEALSRSL PTMGRLQMLG
   721  LAGSKITARG ISHLVKALPL CPQLKEVSFR DNQLSDQVVL NIVEVLPHLP RLRKLDLSSN
   781  SICVSTLLCL ARVAVTCPTV RMLQAREADL IFLLSPPTET TAELQRAPDL QESDGQRKGA
   841  QSRSLTLRLQ KCQLQVHDAE ALIALLQEGP HLEEVDLSGN QLEDEGCRLM AEAASQLHIA
   901  RKLDLSNNGL SVAGVHCVLR AVSACWTLAE LHISLQHKTV IFMFAQEPEE QKGPQERAAF
   961  LDSLMLQMPS ELPLSSRRMR LTHCGLQEKH LEQLCKALGG SCHLGHLHLD FSGNALGDEG
  1021  AARLAQLLPG LGALQSLNLS ENGLSLDAVL GLVRCFSTLQ WLFRLDISFE SQHILLRGDK
  1081  TSRDMWATGS LPDFPAAAKF LGFRQRCIPR SLCLSECPLE PPSLTRLCAT LKDCPGPLEL
  1141  QLSCEFLSDQ SLETLLDCLP QLPQLSLLQL SQTGLSPKSP FLLANTLSLC PRVKKVDLRS
  1201  LHHATLHFRS NEEEEGVCCG RFTGCSLSQE HVESLCWLLS KCKDLSQVDL SANLLGDSGL
  1261  RCLLECLPQV PISGLLDLSH NSISQESALY LLETLPSCPR VREASVNLGS EQSFRIHFSR
  1321  EDQAGKTLRL SECSFRPEHV SRLATGLSKS LQLTELTLTQ CCLGQKQLAI LLSLVGRPAG
  1381  LFSLRVQEPW ADRARVLSLL EVCAQASGSV TEISISETQQ QLCVQLEFPR QEENPEAVAL
  1441  RLAHCDLGAH HSLLVGQLME TCARLQQLSL SQVNLCEDDD ASSLLLQSLL LSLSELKTFR
  1501  LTSSCVSTEG LAHLASGLGH CHHLEELDLS NNQFDEEGTK ALMRALEGKW MLKRLDLSHL
  1561  LLNSSTLALL THRLSQMTCL QSLRLNRNSI GDVGCCHLSE ALRAATSLEE LDLSHNQIGD
  1621  AGVQHLATIL PGLPELRKID LSGNSISSAG GVQLAESLVL CRRLEELMLG CNALGDPTAL
  1681  GLAQELPQHL RVLHLPFSHL GPGGALSLAQ ALDGSPHLEE ISLAENNLAG GVLRFCMELP
  1741  LLRQIDLVSC KIDNQTAKLL TSSFTSCPAL EVILLSWNLL GDEAAAELAQ VLPQMGRLKR
  1801  VDLEKNQITA LGAWLLAEGL AQGSSIQVIR LWNNPIPCDM AQHLKSQEPR LDFAFFDNQP
  1861  QAPWGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

34 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0

gnomAD missense Z

2.01

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response to virus
• innate immune response
• negative regulation of NF-kappaB transcription factor activity
• negative regulation of type I interferon-mediated signaling pathway
• positive regulation of MHC class I biosynthetic process
• positive regulation of transcription by RNA polymerase II
• positive regulation of type I interferon-mediated signaling pathway
• positive regulation of type II interferon-mediated signaling pathway
• regulation of kinase activity
• response to bacterium

Molecular functions

• ATP binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• centrosome
• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• Leucine-rich repeat, cysteine-containing subtype
• NACHT nucleoside triphosphatase
• P-loop containing nucleoside triphosphate hydrolase
• Leucine-rich repeat domain superfamily
• NACHT, LRR and PYD domains-containing protein, helical domain HD2
• NACHT domain
• Leucine Rich repeat
• NLRC4 helical domain HD2
• NLRC5, atypical caspase recruitment domain
• Atypical caspase recruitment domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Immunity
• Innate immunity
• Leucine-rich repeat
• Nucleotide-binding
• Repeat

InteractionsUniProt · HPA

Protein binding partners of NLRC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CHUK
• IFIH1
• IKBKB
• RIGI