Seroatlas · Human Serome Atlas

NLRX1

NLR family member X1

Also known as: CLR11.3, NLRX1_HUMAN, NOD9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UT6
Gene: NLRX1
Ensembl: ENSG00000160703
Chromosome: 11
Canonical length: 975 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Mitochondria
Quaternary structure: Homohexamer

OverviewNCBI Gene

The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

975 residues, UniProt reviewed canonical sequence.

>Q86UT6|NLRX1
     1  MRWGHHLPRA SWGSGFRRAL QRPDDRIPFL IHWSWPLQGE RPFGPPRAFI RHHGSSVDSA
    61  PPPGRHGRLF PSASATEAIQ RHRRNLAEWF SRLPREERQF GPTFALDTVH VDPVIRESTP
   121  DELLRPPAEL ALEHQPPQAG LPPLALSQLF NPDACGRRVQ TVVLYGTVGT GKSTLVRKMV
   181  LDWCYGRLPA FELLIPFSCE DLSSLGPAPA SLCQLVAQRY TPLKEVLPLM AAAGSHLLFV
   241  LHGLEHLNLD FRLAGTGLCS DPEEPQEPAA IIVNLLRKYM LPQASILVTT RPSAIGRIPS
   301  KYVGRYGEIC GFSDTNLQKL YFQLRLNQPY CGYAVGGSGV SATPAQRDHL VQMLSRNLEG
   361  HHQIAAACFL PSYCWLVCAT LHFLHAPTPA GQTLTSIYTS FLRLNFSGET LDSTDPSNLS
   421  LMAYAARTMG KLAYEGVSSR KTYFSEEDVC GCLEAGIRTE EEFQLLHIFR RDALRFFLAP
   481  CVEPGRAGTF VFTVPAMQEY LAALYIVLGL RKTTLQKVGK EVAELVGRVG EDVSLVLGIM
   541  AKLLPLRALP LLFNLIKVVP RVFGRMVGKS REAVAQAMVL EMFREEDYYN DDVLDQMGAS
   601  ILGVEGPRRH PDEPPEDEVF ELFPMFMGGL LSAHNRAVLA QLGCPIKNLD ALENAQAIKK
   661  KLGKLGRQVL PPSELLDHLF FHYEFQNQRF SAEVLSSLRQ LNLAGVRMTP VKCTVVAAVL
   721  GSGRHALDEV NLASCQLDPA GLRTLLPVFL RARKLGLQLN SLGPEACKDL RDLLLHDQCQ
   781  ITTLRLSNNP LTAAGVAVLM EGLAGNTSVT HLSLLHTGLG DEGLELLAAQ LDRNRQLQEL
   841  NVAYNGAGDT AALALARAAR EHPSLELLHL YFNELSSEGR QVLRDLGGAA EGGARVVVSL
   901  TEGTAVSEYW SVILSEVQRN LNSWDRARVQ RHLELLLRDL EDSRGATLNP WRKAQLLRVE
   961  GEVRALLEQL GSSGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

esophagus: 39 nTPM
skeletal muscle: 23 nTPM
skin: 18 nTPM
tonsil: 13 nTPM
tongue: 13 nTPM
heart muscle: 13 nTPM

Single-cell type

esophageal apical cells: 208 nCPM
esophageal suprabasal cells: 91 nCPM
megakaryocytes: 43 nCPM
esophageal basal cells: 34 nCPM
cone photoreceptor cells: 33 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

eosinophil: 16 nTPM
neutrophil: 8.4 nTPM
classical monocyte: 3.5 nTPM
basophil: 2.9 nTPM
total PBMC: 2.3 nTPM
myeloid DC: 2.1 nTPM

Brain region

choroid plexus: 10 nTPM
pons: 8 nTPM
medulla oblongata: 7.8 nTPM
midbrain: 7.5 nTPM
spinal cord: 7.4 nTPM
white matter: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat
NACHT nucleoside triphosphatase
P-loop containing nucleoside triphosphate hydrolase
Leucine-rich repeat domain superfamily
NOD-like receptor
NACHT domain
Leucine Rich repeat
NLR family member X1, C-terminal domain
NLR family member X1, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NLRX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NLRX1 as an antibody target. Whether an autoantibody or antibody against NLRX1 could matter depends on whether native NLRX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NLRX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NLRX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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