Seroatlas · Human Serome Atlas

RRAGA

Ras-related GTP-binding protein A

Also known as: FIP-1, RAGA, RRAGA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L523
Gene
RRAGA
Ensembl
ENSG00000155876
Chromosome
9
Canonical length
313 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and tumor necrosis factor-mediated signaling pathway. Located in GATOR1 complex; lysosome; and nucleoplasm. Part of FNIP-folliculin RagC/D GAP. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q7L523|RRAGA
     1  MPNTAMKKKV LLMGKSGSGK TSMRSIIFAN YIARDTRRLG ATIDVEHSHV RFLGNLVLNL
    61  WDCGGQDTFM ENYFTSQRDN IFRNVEVLIY VFDVESRELE KDMHYYQSCL EAILQNSPDA
   121  KIFCLVHKMD LVQEDQRDLI FKEREEDLRR LSRPLECACF RTSIWDETLY KAWSSIVYQL
   181  IPNVQQLEMN LRNFAQIIEA DEVLLFERAT FLVISHYQCK EQRDVHRFEK ISNIIKQFKL
   241  SCSKLAASFQ SMEVRNSNFA AFIDIFTSNT YVMVVMSDPS IPSAATLINI RNARKHFEKL
   301  ERVDGPKHSL LMR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRAGA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 123 nTPM
  • cerebral cortex: 98 nTPM
  • tongue: 98 nTPM
  • hypothalamus: 90 nTPM
  • blood vessel: 89 nTPM
  • endometrium: 86 nTPM

Single-cell type

  • decidual stromal cells: 221 nCPM
  • late primary spermatocytes: 171 nCPM
  • cytotrophoblasts: 153 nCPM
  • fallopian tube ciliated cells: 149 nCPM
  • esophageal apical cells: 141 nCPM
  • esophageal suprabasal cells: 140 nCPM

Immune cell

  • basophil: 156 nTPM
  • eosinophil: 148 nTPM
  • non-classical monocyte: 110 nTPM
  • total PBMC: 108 nTPM
  • T-reg: 100 nTPM
  • intermediate monocyte: 98 nTPM

Brain region

  • white matter: 102 nTPM
  • hypothalamus: 101 nTPM
  • spinal cord: 94 nTPM
  • cerebral cortex: 90 nTPM
  • thalamus: 89 nTPM
  • pons: 89 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.36
gnomAD missense Z
2.99
DepMap mean gene effect
-0.42
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRAGA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRAGA as an antibody target. Whether an autoantibody or antibody against RRAGA could matter depends on whether native RRAGA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRAGA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRAGA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RRAGA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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