Seroatlas · Human Serome Atlas

SEPTIN1

Septin-1

Also known as: DIFF6, PNUTL3, SEPT1, SEPT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WYJ6
Gene
SEPTIN1
Ensembl
ENSG00000180096
Chromosome
16
Canonical length
372 aa
Protein class
Predicted intracellular proteins
Subcellular location
Actin filaments

OverviewNCBI Gene

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q8WYJ6|SEPTIN1
     1  MAGGVMDKEY VGFAALPNQL HRKSVKKGFD FTLMVAGESG LGKSTLINSL FLTNLYEDRQ
    61  VPEASARLTQ TLAIERRGVE IEEGGVKVKL TLVDTPGFGD SVDCSDCWLP VVKFIEEQFE
   121  QYLRDESGLN RKNIQDSRVH CCLYFISPFG RGLRPLDVAF LRAVHEKVNI IPVIGKADAL
   181  MPQETQALKQ KIRDQLKEEE IHIYQFPECD SDEDEDFKRQ DAEMKESIPF AVVGSCEVVR
   241  DGGNRPVRGR RYSWGTVEVE NPHHCDFLNL RRMLVQTHLQ DLKEVTHDLL YEGYRARCLQ
   301  SLARPGARDR ASRSKLSRQS ATEIPLPMLP LADTEKLIRE KDEELRRMQE MLEKMQAQMQ
   361  QSQAQGEQSD AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 49 nTPM
  • lymph node: 36 nTPM
  • small intestine: 24 nTPM
  • thymus: 22 nTPM
  • appendix: 17 nTPM
  • tonsil: 14 nTPM

Single-cell type

  • platelets: 112 nCPM
  • t-cells: 96 nCPM
  • megakaryocytes: 74 nCPM
  • nk-cells: 72 nCPM
  • pdcs: 70 nCPM
  • ovarian stromal cells: 62 nCPM

Immune cell

  • gdT-cell: 408 nTPM
  • T-reg: 398 nTPM
  • memory CD8 T-cell: 367 nTPM
  • memory CD4 T-cell: 360 nTPM
  • total PBMC: 344 nTPM
  • plasmacytoid DC: 339 nTPM

Brain region

  • thalamus: 1.6 nTPM
  • cerebral cortex: 0.9 nTPM
  • basal ganglia: 0.8 nTPM
  • cerebellum: 0.7 nTPM
  • spinal cord: 0.4 nTPM
  • amygdala: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN1 as an antibody target. Whether an autoantibody or antibody against SEPTIN1 could matter depends on whether native SEPTIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEPTIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEPTIN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...