Seroatlas · Human Serome Atlas

RHOU

Rho-related GTP-binding protein RhoU

Also known as: ARHU, CDC42L1, DJ646B12.2, fJ646B12.2, FLJ10616, hG28K, RHOU_HUMAN, WRCH-1, WRCH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L0Q8
Gene
RHOU
Ensembl
ENSG00000116574
Chromosome
1
Canonical length
258 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Primary cilium

OverviewNCBI Gene

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>Q7L0Q8|RHOU
     1  MPPQQGDPAF PDRCEAPPVP PRRERGGRGG RGPGEPGGRG RAGGAEGRGV KCVLVGDGAV
    61  GKTSLVVSYT TNGYPTEYIP TAFDNFSAVV SVDGRPVRLQ LCDTAGQDEF DKLRPLCYTN
   121  TDIFLLCFSV VSPSSFQNVS EKWVPEIRCH CPKAPIILVG TQSDLREDVK VLIELDKCKE
   181  KPVPEEAAKL CAEEIKAASY IECSALTQKN LKEVFDAAIV AGIQYSDTQQ QPKKSKSRTP
   241  DKMKNLSKSW WKKYCCFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOU can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 67 nTPM
  • hippocampal formation: 48 nTPM
  • midbrain: 44 nTPM
  • basal ganglia: 42 nTPM
  • skeletal muscle: 39 nTPM
  • amygdala: 35 nTPM

Single-cell type

  • oligodendrocytes: 189 nCPM
  • oligodendrocyte progenitor cells: 40 nCPM
  • papillary tip epithelial cells: 35 nCPM
  • astrocytes: 31 nCPM
  • ependymal cells: 19 nCPM
  • bergmann glia: 16 nCPM

Immune cell

  • MAIT T-cell: 0.8 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • intermediate monocyte: 0.5 nTPM
  • eosinophil: 0.4 nTPM
  • gdT-cell: 0.4 nTPM
  • myeloid DC: 0.4 nTPM

Brain region

  • white matter: 68 nTPM
  • basal ganglia: 54 nTPM
  • thalamus: 50 nTPM
  • midbrain: 49 nTPM
  • medulla oblongata: 44 nTPM
  • cerebral cortex: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.08
gnomAD missense Z
0.95
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOU in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOU as an antibody target. Whether an autoantibody or antibody against RHOU could matter depends on whether native RHOU is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOU is annotated at the cell surface, where native RHOU is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOU as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RHOU. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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