Seroatlas · Human Serome Atlas

N4BP2L1

NEDD4-binding protein 2-like 1

Also known as: CG018, N42L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TBK1
Gene: N4BP2L1
Ensembl: ENSG00000139597
Chromosome: 13
Canonical length: 243 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

No narrative summary is available for N4BP2L1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q5TBK1|N4BP2L1
     1  MEDSFLQSFG RLSLQPQQQQ QRQRPPRPPP RGTPPRRHSF RKHLYLLRGL PGSGKTTLAR
    61  QLQHDFPRAL IFSTDDFFFR EDGAYEFNPD FLEEAHEWNQ KRARKAMRNG ISPIIIDNTN
   121  LHAWEMKPYA VMALENNYEV IFREPDTRWK FNVQELARRN IHGVSREKIH RMKERYEHDV
   181  TFHSVLHAEK PSRMNRNQDR NNALPSNNAR YWNSYTEFPN RRAHGGFTNE SSYHRRGGCH
   241  HGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against N4BP2L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

liver: 81 nTPM
bone marrow: 47 nTPM
ovary: 44 nTPM
cerebellum: 39 nTPM
pituitary gland: 36 nTPM
basal ganglia: 33 nTPM

Single-cell type

pdcs: 237 nCPM
choroid plexus epithelial cells: 175 nCPM
hepatocytes: 162 nCPM
breast lactating cells: 145 nCPM
platelets: 137 nCPM
corticotrophs: 108 nCPM

Immune cell

basophil: 59 nTPM
plasmacytoid DC: 56 nTPM
classical monocyte: 49 nTPM
intermediate monocyte: 47 nTPM
myeloid DC: 44 nTPM
total PBMC: 37 nTPM

Brain region

hypothalamus: 35 nTPM
cerebral cortex: 29 nTPM
basal ganglia: 28 nTPM
cerebellum: 25 nTPM
white matter: 25 nTPM
choroid plexus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.84
gnomAD missense Z: 1.33
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Developmental protein

InteractionsUniProt · HPA

Protein binding partners of N4BP2L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads N4BP2L1 as an antibody target. Whether an autoantibody or antibody against N4BP2L1 could matter depends on whether native N4BP2L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

N4BP2L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label N4BP2L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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