Seroatlas · Human Serome Atlas

RND2

Rho-related GTP-binding protein RhoN

Also known as: ARHN, Rho7, RhoN, RND2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52198
Gene: RND2
Ensembl: ENSG00000108830
Chromosome: 17
Canonical length: 227 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>P52198|RND2
     1  MEGQSGRCKI VVVGDAECGK TALLQVFAKD AYPGSYVPTV FENYTASFEI DKRRIELNMW
    61  DTSGSSYYDN VRPLAYPDSD AVLICFDISR PETLDSVLKK WQGETQEFCP NAKVVLVGCK
   121  LDMRTDLATL RELSKQRLIP VTHEQGTVLA KQVGAVSYVE CSSRSSERSV RDVFHVATVA
   181  SLGRGHRQLR RTDSRRGMQR SAQLSGRPDR GNEGEIHKDR AKSCNLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RND2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

midbrain: 95 nTPM
spinal cord: 91 nTPM
hypothalamus: 72 nTPM
basal ganglia: 43 nTPM
testis: 36 nTPM
amygdala: 28 nTPM

Single-cell type

late spermatids: 1,019 nCPM
early spermatids: 133 nCPM
late primary spermatocytes: 108 nCPM
oocytes: 28 nCPM
other brain neurons: 22 nCPM
oligodendrocyte progenitor cells: 20 nCPM

Immune cell

basophil: 0.4 nTPM
memory B-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

medulla oblongata: 114 nTPM
midbrain: 106 nTPM
pons: 89 nTPM
spinal cord: 81 nTPM
hypothalamus: 80 nTPM
cerebellum: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.73
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small GTPase
Small GTPase Rho
Small GTP-binding domain
P-loop containing nucleoside triphosphate hydrolase
Ras family
Rho-related GTP-binding protein RhoN

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RND2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RND2 as an antibody target. Whether an autoantibody or antibody against RND2 could matter depends on whether native RND2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RND2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RND2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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