Seroatlas · Human Serome Atlas

GBP4

Guanylate-binding protein 4

Also known as: GBP4_HUMAN, Mpa2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PP9
Gene: GBP4
Ensembl: ENSG00000162654
Chromosome: 1
Canonical length: 640 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

640 residues, UniProt reviewed canonical sequence.

>Q96PP9|GBP4
     1  MGERTLHAAV PTPGYPESES IMMAPICLVE NQEEQLTVNS KALEILDKIS QPVVVVAIVG
    61  LYRTGKSYLM NRLAGKRNGF PLGSTVQSET KGIWMWCVPH LSKPNHTLVL LDTEGLGDVE
   121  KSNPKNDSWI FALAVLLSSS FVYNSVSTIN HQALEQLHYV TELAELIRAK SCPRPDEAED
   181  SSEFASFFPD FIWTVRDFTL ELKLDGNPIT EDEYLENALK LIPGKNPKIQ NSNMPRECIR
   241  HFFRKRKCFV FDRPTNDKQY LNHMDEVPEE NLERHFLMQS DNFCSYIFTH AKTKTLREGI
   301  IVTGKRLGTL VVTYVDAINS GAVPCLENAV TALAQLENPA AVQRAADHYS QQMAQQLRLP
   361  TDTLQELLDV HAACEREAIA VFMEHSFKDE NHEFQKKLVD TIEKKKGDFV LQNEEASAKY
   421  CQAELKRLSE HLTESILRGI FSVPGGHNLY LEEKKQVEWD YKLVPRKGVK ANEVLQNFLQ
   481  SQVVVEESIL QSDKALTAGE KAIAAERAMK EAAEKEQELL REKQKEQQQM MEAQERSFQE
   541  YMAQMEKKLE EERENLLREH ERLLKHKLKV QEEMLKEEFQ KKSEQLNKEI NQLKEKIEST
   601  KNEQLRLLKI LDMASNIMIV TLPGASKLLG VGTKYLGSRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

lymph node: 32 nTPM
lung: 29 nTPM
appendix: 28 nTPM
spleen: 27 nTPM
ovary: 16 nTPM
liver: 13 nTPM

Single-cell type

vascular endothelial cells: 83 nCPM
hematopoietic stem cells: 56 nCPM
esophageal apical cells: 42 nCPM
nk-cells: 41 nCPM
kupffer cells: 38 nCPM
foveolar cells: 27 nCPM

Immune cell

non-classical monocyte: 15 nTPM
intermediate monocyte: 14 nTPM
NK-cell: 14 nTPM
T-reg: 9 nTPM
memory CD8 T-cell: 7.9 nTPM
memory CD4 T-cell: 7.6 nTPM

Brain region

pons: 24 nTPM
medulla oblongata: 23 nTPM
cerebral cortex: 17 nTPM
thalamus: 17 nTPM
spinal cord: 16 nTPM
cerebellum: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GBP4.

Disease | ImmuneIEDB

Conditions an epitope on GBP4 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GBP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IRF7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GBP4 as an antibody target. Whether an autoantibody or antibody against GBP4 could matter depends on whether native GBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GBP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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