Seroatlas · Human Serome Atlas

KIFC1

Kinesin-like protein KIFC1

Also known as: HSET, KIFC1_HUMAN, KNSL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BW19
Gene
KIFC1
Ensembl
ENSG00000237649
Chromosome
6
Canonical length
673 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Primary cilium,Centrosome,Basal body

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and minus-end-directed microtubule motor activity. Involved in mitotic metaphase chromosome alignment and mitotic spindle assembly. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>Q9BW19|KIFC1
     1  MDPQRSPLLE VKGNIELKRP LIKAPSQLPL SGSRLKRRPD QMEDGLEPEK KRTRGLGATT
    61  KITTSHPRVP SLTTVPQTQG QTTAQKVSKK TGPRCSTAIA TGLKNQKPVP AVPVQKSGTS
   121  GVPPMAGGKK PSKRPAWDLK GQLCDLNAEL KRCRERTQTL DQENQQLQDQ LRDAQQQVKA
   181  LGTERTTLEG HLAKVQAQAE QGQQELKNLR ACVLELEERL STQEGLVQEL QKKQVELQEE
   241  RRGLMSQLEE KERRLQTSEA ALSSSQAEVA SLRQETVAQA ALLTEREERL HGLEMERRRL
   301  HNQLQELKGN IRVFCRVRPV LPGEPTPPPG LLLFPSGPGG PSDPPTRLSL SRSDERRGTL
   361  SGAPAPPTRH DFSFDRVFPP GSGQDEVFEE IAMLVQSALD GYPVCIFAYG QTGSGKTFTM
   421  EGGPGGDPQL EGLIPRALRH LFSVAQELSG QGWTYSFVAS YVEIYNETVR DLLATGTRKG
   481  QGGECEIRRA GPGSEELTVT NARYVPVSCE KEVDALLHLA RQNRAVARTA QNERSSRSHS
   541  VFQLQISGEH SSRGLQCGAP LSLVDLAGSE RLDPGLALGP GERERLRETQ AINSSLSTLG
   601  LVIMALSNKE SHVPYRNSKL TYLLQNSLGG SAKMLMFVNI SPLEENVSES LNSLRFASKV
   661  NQCVIGTAQA NRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIFC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 44 nTPM
  • bone marrow: 37 nTPM
  • tonsil: 23 nTPM
  • lymph node: 23 nTPM
  • testis: 13 nTPM
  • esophagus: 12 nTPM

Single-cell type

  • extravillous trophoblasts: 25 nCPM
  • erythrocyte progenitors: 23 nCPM
  • monocyte progenitors: 23 nCPM
  • megakaryocyte progenitors: 20 nCPM
  • early spermatids: 19 nCPM
  • enteric transient amplifying cells: 17 nCPM

Immune cell

  • T-reg: 1.6 nTPM
  • NK-cell: 1 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • total PBMC: 0.5 nTPM
  • basophil: 0.4 nTPM
  • non-classical monocyte: 0.3 nTPM

Brain region

  • cerebral cortex: 2.5 nTPM
  • hippocampal formation: 1.4 nTPM
  • pons: 1.4 nTPM
  • thalamus: 1.4 nTPM
  • white matter: 1 nTPM
  • choroid plexus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0
gnomAD missense Z
1.68
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIFC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIFC1 as an antibody target. Whether an autoantibody or antibody against KIFC1 could matter depends on whether native KIFC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIFC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIFC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIFC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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