Seroatlas · Human Serome Atlas

DDX18

ATP-dependent RNA helicase DDX18

Also known as: DDX18_HUMAN, Has1, MrDb

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVP1
Gene: DDX18
Ensembl: ENSG00000088205
Chromosome: 2
Canonical length: 670 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>Q9NVP1|DDX18
     1  MSHLPMKLLR KKIEKRNLKL RQRNLKFQGA SNLTLSETQN GDVSEETMGS RKVKKSKQKP
    61  MNVGLSETQN GGMSQEAVGN IKVTKSPQKS TVLTNGEAAM QSSNSESKKK KKKKRKMVND
   121  AEPDTKKAKT ENKGKSEEES AETTKETENN VEKPDNDEDE SEVPSLPLGL TGAFEDTSFA
   181  SLCNLVNENT LKAIKEMGFT NMTEIQHKSI RPLLEGRDLL AAAKTGSGKT LAFLIPAVEL
   241  IVKLRFMPRN GTGVLILSPT RELAMQTFGV LKELMTHHVH TYGLIMGGSN RSAEAQKLGN
   301  GINIIVATPG RLLDHMQNTP GFMYKNLQCL VIDEADRILD VGFEEELKQI IKLLPTRRQT
   361  MLFSATQTRK VEDLARISLK KEPLYVGVDD DKANATVDGL EQGYVVCPSE KRFLLLFTFL
   421  KKNRKKKLMV FFSSCMSVKY HYELLNYIDL PVLAIHGKQK QNKRTTTFFQ FCNADSGTLL
   481  CTDVAARGLD IPEVDWIVQY DPPDDPKEYI HRVGRTARGL NGRGHALLIL RPEELGFLRY
   541  LKQSKVPLSE FDFSWSKISD IQSQLEKLIE KNYFLHKSAQ EAYKSYIRAY DSHSLKQIFN
   601  VNNLNLPQVA LSFGFKVPPF VDLNVNSNEG KQKKRGGGGG FGYQKTKKVE KSKIFKHISK
   661  KSSDSRQFSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

tonsil: 39 nTPM
lymph node: 39 nTPM
liver: 33 nTPM
thymus: 32 nTPM
urinary bladder: 31 nTPM
breast: 31 nTPM

Single-cell type

pdcs: 313 nCPM
oocytes: 230 nCPM
hepatocytes: 215 nCPM
plasma cells: 214 nCPM
basal keratinocytes: 206 nCPM
erythrocyte progenitors: 176 nCPM

Immune cell

memory B-cell: 38 nTPM
naive CD4 T-cell: 36 nTPM
plasmacytoid DC: 34 nTPM
non-classical monocyte: 33 nTPM
MAIT T-cell: 32 nTPM
total PBMC: 32 nTPM

Brain region

white matter: 19 nTPM
spinal cord: 15 nTPM
cerebellum: 13 nTPM
medulla oblongata: 13 nTPM
hypothalamus: 13 nTPM
basal ganglia: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDX18.

Disease | ImmuneIEDB

Conditions an epitope on DDX18 was assayed in.

influenza T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.14
gnomAD missense Z: 0.47
DepMap mean gene effect: -1.63
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDX18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX18 as an antibody target. Whether an autoantibody or antibody against DDX18 could matter depends on whether native DDX18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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