RHOQ

Protein identityUniProt · HPA

UniProt accession

P17081

Gene

RHOQ

Ensembl

ENSG00000119729

Chromosome

2

Canonical length

205 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>P17081|RHOQ
     1  MAHGPGALML KCVVVGDGAV GKTCLLMSYA NDAFPEEYVP TVFDHYAVSV TVGGKQYLLG
    61  LYDTAGQEDY DRLRPLSYPM TDVFLICFSV VNPASFQNVK EEWVPELKEY APNVPFLLIG
   121  TQIDLRDDPK TLARLNDMKE KPICVEQGQK LAKEIGACCY VECSALTQKG LKTVFDEAII
   181  AILTPKKHTV KKRIGSRCIN CCLIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

169 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.44

gnomAD pLI

0.86

gnomAD missense Z

1.31

DepMap mean gene effect

-0.82

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament organization
• cellular response to insulin stimulus
• cortical actin cytoskeleton organization
• endocytosis
• establishment of cell polarity
• GTP metabolic process
• insulin receptor signaling pathway
• negative regulation of protein localization to plasma membrane
• positive regulation of D-glucose import
• positive regulation of filopodium assembly
• positive regulation of transcription by RNA polymerase II
• regulation of actin cytoskeleton organization
• regulation of cell shape
• signal transduction
• small GTPase-mediated signal transduction

Molecular functions

• GBD domain binding
• GTP binding
• GTPase activity
• profilin binding
• protein kinase binding

Cellular components

• actin filament
• extracellular exosome
• Golgi-associated vesicle membrane
• membrane raft
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTPase Rho
• Small GTP-binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Ras family

KeywordsUniProt

• Cell membrane
• Cytoplasm
• GTP-binding
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Prenylation

InteractionsUniProt · HPA

Protein binding partners of RHOQ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDC42EP1
• CDC42EP2
• CDC42EP3
• CDC42EP4
• EXO70
• GOPC
• PARD6A
• PARD6G
• PARD6B