Seroatlas · Human Serome Atlas

DDX49

Probable ATP-dependent RNA helicase DDX49

Also known as: Dbp8, DDX49_HUMAN, FLJ10432

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6V7
Gene: DDX49
Ensembl: ENSG00000105671
Chromosome: 19
Canonical length: 483 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables RNA helicase activity. Involved in positive regulation of cell growth and regulation of rRNA stability. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>Q9Y6V7|DDX49
     1  MAGFAELGLS SWLVEQCRQL GLKQPTPVQL GCIPAILEGR DCLGCAKTGS GKTAAFVLPI
    61  LQKLSEDPYG IFCLVLTPTR ELAYQIAEQF RVLGKPLGLK DCIIVGGMDM VAQALELSRK
   121  PHVVIATPGR LADHLRSSNT FSIKKIRFLV MDEADRLLEQ GCTDFTVDLE AILAAVPARR
   181  QTLLFSATLT DTLRELQGLA TNQPFFWEAQ APVSTVEQLD QRYLLVPEKV KDAYLVHLIQ
   241  RFQDEHEDWS IIIFTNTCKT CQILCMMLRK FSFPTVALHS MMKQKERFAA LAKFKSSIYR
   301  ILIATDVASR GLDIPTVQVV INHNTPGLPK IYIHRVGRTA RAGRQGQAIT LVTQYDIHLV
   361  HAIEEQIKKK LEEFSVEEAE VLQILTQVNV VRRECEIKLE AAHFDEKKEI NKRKQLILEG
   421  KDPDLEAKRK AELAKIKQKN RRFKEKVEET LKRQKAGRAG HKGRPPRTPS GSHSGPVPSQ
   481  GLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX49 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 34 nTPM
skin: 28 nTPM
esophagus: 27 nTPM
liver: 27 nTPM
bone marrow: 22 nTPM
hippocampal formation: 22 nTPM

Single-cell type

late spermatids: 184 nCPM
esophageal basal cells: 78 nCPM
esophageal suprabasal cells: 72 nCPM
extravillous trophoblasts: 69 nCPM
cytotrophoblasts: 62 nCPM
migrating cytotrophoblasts: 58 nCPM

Immune cell

myeloid DC: 31 nTPM
intermediate monocyte: 26 nTPM
classical monocyte: 22 nTPM
NK-cell: 20 nTPM
non-classical monocyte: 18 nTPM
T-reg: 18 nTPM

Brain region

white matter: 23 nTPM
hippocampal formation: 21 nTPM
cerebellum: 20 nTPM
cerebral cortex: 20 nTPM
spinal cord: 20 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.96
DepMap mean gene effect: -1.54
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDX49 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

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Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX49 as an antibody target. Whether an autoantibody or antibody against DDX49 could matter depends on whether native DDX49 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX49 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX49 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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