NLRP9

Protein identityUniProt · HPA

UniProt accession

Q7RTR0

Gene

NLRP9

Ensembl

ENSG00000185792

Chromosome

19

Canonical length

991 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

991 residues, UniProt reviewed canonical sequence.

>Q7RTR0|NLRP9
     1  MAESFFSDFG LLWYLKELRK EEFWKFKELL KQPLEKFELK PIPWAELKKA SKEDVAKLLD
    61  KHYPGKQAWE VTLNLFLQIN RKDLWTKAQE EMRNKLNPYR KHMKETFQLI WEKETCLHVP
   121  EHFYKETMKN EYKELNDAYT AAARRHTVVL EGPDGIGKTT LLRKVMLDWA EGNLWKDRFT
   181  FVFFLNVCEM NGIAETSLLE LLSRDWPESS EKIEDIFSQP ERILFIMDGF EQLKFNLQLK
   241  ADLSDDWRQR QPMPIILSSL LQKKMLPESS LLIALGKLAM QKHYFMLRHP KLIKLLGFSE
   301  SEKKSYFSYF FGEKSKALKV FNFVRDNGPL FILCHNPFTC WLVCTCVKQR LERGEDLEIN
   361  SQNTTYLYAS FLTTVFKAGS QSFPPKVNRA RLKSLCALAA EGIWTYTFVF SHGDLRRNGL
   421  SESEGVMWVG MRLLQRRGDC FAFMHLCIQE FCAAMFYLLK RPKDDPNPAI GSITQLVRAS
   481  VVQPQTLLTQ VGIFMFGIST EEIVSMLETS FGFPLSKDLK QEITQCLESL SQCEADREAI
   541  AFQELFIGLF ETQEKEFVTK VMNFFEEVFI YIGNIEHLVI ASFCLKHCQH LTTLRMCVEN
   601  IFPDDSGCIS DYNEKLVYWR ELCSMFITNK NFQILDMENT SLDDPSLAIL CKALAQPVCK
   661  LRKLIFTSVY FGHDSELFKA VLHNPHLKLL SLYGTSLSQS DIRHLCETLK HPMCKIEELI
   721  LGKCDISSEV CEDIASVLAC NSKLKHLSLV ENPLRDEGMT LLCEALKHSH CALERLMLMY
   781  CCLTSVSCDS ISEVLLCSKS LSLLDLGSNA LEDNGVASLC AALKHPGCSI RELWLMGCFL
   841  TSDSCKDIAA VLICNGKLKT LKLGHNEIGD TGVRQLCAAL QHPHCKLECL GLQTCPITRA
   901  CCDDIAAALI ACKTLRSLNL DWIALDADAV VVLCEALSHP DCALQMLGLH KSGFDEETQK
   961  ILMSVEEKIP HLTISHGPWI DEEYKIRGVL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

1.9 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

-0.64

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response to virus
• innate immune response
• positive regulation of interleukin-18 production
• pyroptotic inflammatory response
• regulation of inflammatory response

Molecular functions

• ATP binding

Cellular components

• canonical inflammasome complex
• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• DAPIN domain
• NACHT nucleoside triphosphatase
• Death-like domain superfamily
• P-loop containing nucleoside triphosphate hydrolase
• Leucine-rich repeat domain superfamily
• NOD1/2, winged helix domain
• NACHT, LRR and PYD domains-containing protein, helical domain HD2
• NLRP family, innate immunity and inflammation regulators
• PAAD/DAPIN/Pyrin domain
• NACHT domain
• Leucine Rich repeat
• NLRC4 helical domain HD2
• NOD2 winged helix domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Immunity
• Inflammasome
• Inflammatory response
• Innate immunity
• Leucine-rich repeat
• Nucleotide-binding
• Repeat