Seroatlas · Human Serome Atlas

CMSS1

Protein CMSS1

Also known as: C3orf26, CMS1_HUMAN, MGC4308

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ75
Gene: CMSS1
Ensembl: ENSG00000184220
Chromosome: 3
Canonical length: 279 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Nucleoli,Mitochondria

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>Q9BQ75|CMSS1
     1  MADDLGDEWW ENQPTGAGSS PEASDGEGEG DTEVMQQETV PVPVPSEKTK QPKECFLIQP
    61  KERKENTTKT RKRRKKKITD VLAKSEPKPG LPEDLQKLMK DYYSSRRLVI ELEELNLPDS
   121  CFLKANDLTH SLSSYLKEIC PKWVKLRKNH SEKKSVLMLI ICSSAVRALE LIRSMTAFRG
   181  DGKVIKLFAK HIKVQAQVKL LEKRVVHLGV GTPGRIKELV KQGGLNLSPL KFLVFDWNWR
   241  DQKLRRMMDI PEIRKEVFEL LEMGVLSLCK SESLKLGLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMSS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 66 nTPM
cerebral cortex: 33 nTPM
blood vessel: 32 nTPM
cerebellum: 32 nTPM
adrenal gland: 31 nTPM
amygdala: 31 nTPM

Single-cell type

myonuclei: 2,411 nCPM
cardiomyocytes: 1,948 nCPM
ependymal cells: 1,030 nCPM
epicardial cells: 778 nCPM
late spermatids: 546 nCPM
early spermatids: 492 nCPM

Immune cell

plasmacytoid DC: 62 nTPM
memory B-cell: 58 nTPM
naive B-cell: 56 nTPM
naive CD8 T-cell: 42 nTPM
naive CD4 T-cell: 41 nTPM
T-reg: 34 nTPM

Brain region

cerebellum: 52 nTPM
medulla oblongata: 46 nTPM
basal ganglia: 44 nTPM
cerebral cortex: 43 nTPM
hypothalamus: 41 nTPM
white matter: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
Protein Cms1
U3-containing 90S pre-ribosomal complex subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CMSS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZBTB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMSS1 as an antibody target. Whether an autoantibody or antibody against CMSS1 could matter depends on whether native CMSS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMSS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMSS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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