MYO1B

Protein identityUniProt · HPA

UniProt accession

O43795

Gene

MYO1B

Ensembl

ENSG00000128641

Chromosome

2

Canonical length

1136 aa

Protein class

Predicted intracellular proteins

Subcellular location

Plasma membrane

OverviewNCBI Gene

Enables ATP binding activity; actin filament binding activity; and microfilament motor activity. Involved in actin filament organization and post-Golgi vesicle-mediated transport. Located in several cellular components, including actin filament; endosome; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1136 residues, UniProt reviewed canonical sequence.

>O43795|MYO1B
     1  MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS
    61  LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL
   121  VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP
   181  LGGVISNYLL EKSRVVKQPR GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA
   241  KVNGVDDAAN FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI
   301  KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD ALAKNLYSRL
   361  FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE QFIINYCNEK LQQIFIELTL
   421  KEEQEEYIRE DIEWTHIDYF NNAIICDLIE NNTNGILAML DEECLRPGTV TDETFLEKLN
   481  QVCATHQHFE SRMSKCSRFL NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ
   541  AMWKASHALI KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND
   601  KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK QTWPHWKGPA
   661  RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR KQRLEDLATL IQKIYRGWKC
   721  RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT KSSALVIQSY IRGWKARKIL RELKHQKRCK
   781  EAVTTIAAYW HGTQARRELR RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA
   841  VAVIWAYWLG LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP
   901  SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD KKALYPSSVG
   961  QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN GKSTSRIFLL TNNNLLLADQ
  1021  KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH LKEGSEAASK GDFLFSSDHL IEMATKLYRT
  1081  TLSQTKQKLN IEISDEFLVQ FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

239 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYO1B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 150 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Colorectal cancer

Disease | ImmuneIEDB

Conditions an epitope on MYO1B was assayed in.

• melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.43

gnomAD pLI

0

gnomAD missense Z

2.43

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament bundle assembly
• actin filament organization
• actin filament-based movement
• endocytosis
• post-Golgi vesicle-mediated transport

Molecular functions

• actin filament binding
• ATP binding
• cadherin binding
• calmodulin binding
• microfilament motor activity
• phosphatidylinositol-3,4,5-trisphosphate binding
• phosphatidylinositol-4,5-bisphosphate binding

Cellular components

• actin cytoskeleton
• actin filament
• brush border
• cell periphery
• cytoplasm
• early endosome
• endosome membrane
• extracellular exosome
• filopodium
• microvillus
• myosin complex
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• IQ motif, EF-hand binding site
• Myosin head, motor domain-like
• Class I myosin tail homology domain
• P-loop containing nucleoside triphosphate hydrolase
• Class I myosin, motor domain
• Kinesin motor domain superfamily
• Myosin head (motor domain)
• IQ calmodulin-binding motif
• Unconventional myosin tail, actin- and lipid-binding

KeywordsUniProt

• Actin-binding
• ATP-binding
• Calmodulin-binding
• Isopeptide bond
• Motor protein
• Myosin
• Nucleotide-binding
• Phosphoprotein
• Repeat
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of MYO1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CALM1
• CALM3
• MYO1C