Seroatlas · Human Serome Atlas

REM1

GTP-binding protein REM 1

Also known as: GES, REM, REM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75628
Gene: REM1
Ensembl: ENSG00000088320
Chromosome: 20
Canonical length: 298 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>O75628|REM1
     1  MTLNTEQEAK TPLHRRASTP LPLSPRGHQP GRLSTVPSTQ SQHPRLGQSA SLNPPTQKPS
    61  PAPDDWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF AGKQERDLHE QLGEDVYERT
   121  LTVDGEDTTL VVVDTWEAEK LDKSWSQESC LQGGSAYVIV YSIADRGSFE SASELRIQLR
   181  RTHQADHVPI ILVGNKADLA RCREVSVEEG RACAVVFDCK FIETSATLQH NVAELFEGVV
   241  RQLRLRRRDS AAKEPPAPRR PASLAQRARR FLARLTARSA RRRALKARSK SCHNLAVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

cervix: 23 nTPM
fallopian tube: 14 nTPM
adipose tissue: 13 nTPM
endometrium: 10 nTPM
vagina: 9.1 nTPM
blood vessel: 8.4 nTPM

Single-cell type

pericytes: 59 nCPM
decidual stromal cells: 38 nCPM
vascular smooth muscle cells: 23 nCPM
fallopian tube ciliated cells: 16 nCPM
peritubular myoid cells: 14 nCPM
fallopian secretory cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.4 nTPM
choroid plexus: 1.3 nTPM
thalamus: 1.2 nTPM
amygdala: 1 nTPM
pons: 0.9 nTPM
midbrain: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REM1 as an antibody target. Whether an autoantibody or antibody against REM1 could matter depends on whether native REM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REM1 is annotated at the cell surface, where native REM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label REM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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