Seroatlas · Human Serome Atlas

IFI44L

Interferon-induced protein 44-like

Also known as: C1orf29, GS3686, IF44L_HUMAN, TLDC5B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53G44
Gene: IFI44L
Ensembl: ENSG00000137959
Chromosome: 1
Canonical length: 452 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to act upstream of or within cellular response to virus. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q53G44|IFI44L
     1  MEVTTRLTWN DENHLRKLLG NVSLSLLYKS SVHGGSIEDM VERCSRQGCT ITMAYIDYNM
    61  IVAFMLGNYI NLHESSTEPN DSLWFSLQKK NDTTEIETLL LNTAPKIIDE QLVCRLSKTD
   121  IFIICRDNKI YLDKMITRNL KLRFYGHRQY LECEVFRVEG IKDNLDDIKR IIKAREHRNR
   181  LLADIRDYRP YADLVSEIRI LLVGPVGSGK SSFFNSVKSI FHGHVTGQAV VGSDITSITE
   241  RYRIYSVKDG KNGKSLPFML CDTMGLDGAE GAGLCMDDIP HILKGCMPDR YQFNSRKPIT
   301  PEHSTFITSP SLKDRIHCVA YVLDINSIDN LYSKMLAKVK QVHKEVLNCG IAYVALLTKV
   361  DDCSEVLQDN FLNMSRSMTS QSRVMNVHKM LGIPISNILM VGNYASDLEL DPMKDILILS
   421  ALRQMLRAAD DFLEDLPLEE TGAIERALQP CI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFI44L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 76 nTPM
spleen: 41 nTPM
bone marrow: 40 nTPM
gallbladder: 30 nTPM
thymus: 30 nTPM
ovary: 24 nTPM

Single-cell type

microglia: 144 nCPM
vascular endothelial cells: 117 nCPM
thymocytes: 109 nCPM
granulosa cells: 105 nCPM
macrophages: 72 nCPM
peritubular myoid cells: 64 nCPM

Immune cell

intermediate monocyte: 11 nTPM
NK-cell: 10 nTPM
classical monocyte: 9.3 nTPM
memory B-cell: 6.7 nTPM
non-classical monocyte: 6.6 nTPM
plasmacytoid DC: 5 nTPM

Brain region

spinal cord: 65 nTPM
medulla oblongata: 64 nTPM
pons: 36 nTPM
white matter: 26 nTPM
midbrain: 25 nTPM
hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -1.21
DepMap mean gene effect: -0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFI44L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FKBP5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFI44L as an antibody target. Whether an autoantibody or antibody against IFI44L could matter depends on whether native IFI44L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFI44L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFI44L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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