Seroatlas · Human Serome Atlas

AGAP2

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Also known as: AGAP2_HUMAN, CENTG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99490
Gene: AGAP2
Ensembl: ENSG00000135439
Chromosome: 12
Canonical length: 1192 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody ring,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

1192 residues, UniProt reviewed canonical sequence.

>Q99490|AGAP2
     1  MSRGAGALQR RTTTYLISLT LVKLESVPPP PPSPSAAAAG AAGARGSETG DPGSPRGAEE
    61  PGKKRHERLF HRQDALWIST SSAGTGGAEP PALSPAPASP ARPVSPAPGR RLSLWAVPPG
   121  PPLSGGLSPD PKPGGAPTSS RRPLLSSPSW GGPEPEGRAG GGIPGSSSPH PGTGSRRLKV
   181  APPPPAPKPC KTVTTSGAKA GGGKGAGSRL SWPESEGKPR VKGSKSSAGT GASVSAAATA
   241  AAAGGGGSTA STSGGVGAGA GARGKLSPRK GKSKTLDNSD LHPGPPAGSP PPLTLPPTPS
   301  PATAVTAASA QPPGPAPPIT LEPPAPGLKR GREGGRASTR DRKMLKFISG IFTKSTGGPP
   361  GSGPLPGPPS LSSGSGSREL LGAELRASPK AVINSQEWTL SRSIPELRLG VLGDARSGKS
   421  SLIHRFLTGS YQVLEKTESE QYKKEMLVDG QTHLVLIREE AGAPDAKFSG WADAVIFVFS
   481  LEDENSFQAV SRLHGQLSSL RGEGRGGLAL ALVGTQDRIS ASSPRVVGDA RARALCADMK
   541  RCSYYETCAT YGLNVDRVFQ EVAQKVVTLR KQQQLLAACK SLPSSPSHSA ASTPVAGQAS
   601  NGGHTSDYSS SLPSSPNVGH RELRAEAAAV AGLSTPGSLH RAAKRRTSLF ANRRGSDSEK
   661  RSLDSRGETT GSGRAIPIKQ SFLLKRSGNS LNKEWKKKYV TLSSNGFLLY HPSINDYIHS
   721  THGKEMDLLR TTVKVPGKRP PRAISAFGPS ASINGLVKDM STVQMGEGLE ATTPMPSPSP
   781  SPSSLQPPPD QTSKHLLKPD RNLARALSTD CTPSGDLSPL SREPPPSPMV KKQRRKKLTT
   841  PSKTEGSAGQ AEAKRKMWKL KSFGSLRNIY KAEENFEFLI VSSTGQTWHF EAASFEERDA
   901  WVQAIESQIL ASLQCCESSK VKLRTDSQSE AVAIQAIRNA KGNSICVDCG APNPTWASLN
   961  LGALICIECS GIHRNLGTHL SRVRSLDLDD WPRELTLVLT AIGNDTANRV WESDTRGRAK
  1021  PSRDSSREER ESWIRAKYEQ LLFLAPLSTS EEPLGRQLWA AVQAQDVATV LLLLAHARHG
  1081  PLDTSVEDPQ LRSPLHLAAE LAHVVITQLL LWYGADVAAR DAQGRTALFY ARQAGSQLCA
  1141  DILLQHGCPG EGGSAATTPS AATTPSITAT PSPRRRSSAA SVGRADAPVA LV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 182 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 182 nTPM
hippocampal formation: 162 nTPM
cerebral cortex: 151 nTPM
basal ganglia: 148 nTPM
amygdala: 131 nTPM
hypothalamus: 36 nTPM

Single-cell type

neutrophils: 57 nCPM
brain excitatory neurons: 41 nCPM
neutrophil progenitors: 40 nCPM
brain inhibitory neurons: 35 nCPM
pericytes: 30 nCPM
hematopoietic stem cells: 24 nCPM

Immune cell

T-reg: 4.1 nTPM
basophil: 3.8 nTPM
neutrophil: 3.8 nTPM
memory CD8 T-cell: 3 nTPM
MAIT T-cell: 2.9 nTPM
memory CD4 T-cell: 2.8 nTPM

Brain region

cerebral cortex: 548 nTPM
hippocampal formation: 451 nTPM
amygdala: 323 nTPM
basal ganglia: 292 nTPM
white matter: 247 nTPM
cerebellum: 160 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 1
gnomAD missense Z: 3.39
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGAP2 as an antibody target. Whether an autoantibody or antibody against AGAP2 could matter depends on whether native AGAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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