Seroatlas · Protein domains

RNA-binding domain superfamily

IPR035979

Definition

Many eukaryotic proteins containing one or more copies of a putative RNA-binding domain of about 90 amino acids are known to bind single-stranded RNAs [[cite:PMID:3072706], [cite:PMID:3192525], [cite:PMID:3313012]]. The largest group of single strand RNA-binding proteins is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence [[cite:PMID:2470643], [cite:PMID:2467746]]. RRM proteins have a variety of RNA binding preferences and functions, and include heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu) [[cite:PMID:3192525], [cite:PMID:3313012], [cite:PMID:2467746]]. The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialised features for protein recognition PMID:15231733. The motif also appears in a few single stranded DNA binding proteins. The typical RRM consists of four anti-parallel β-strands and two α-helices arranged in a β-α-β-β-α-β fold with side chains that stack with RNA bases. Specificity of RNA binding is determined by multiple contacts with surrounding amino acids. A third helix is present during RNA binding in some cases PMID:8290338. The RRM is reviewed in a number of publications [[cite:PMID:1716386], [cite:PMID:15853797], [cite:PMID:16387655]]. This entry also includes some bacterial putative RNA-binding proteins.

250 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

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