Seroatlas · Human Serome Atlas

DNAJC17

DnaJ homolog subfamily C member 17

Also known as: DJC17_HUMAN, FLJ10634

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVM6
Gene: DNAJC17
Ensembl: ENSG00000104129
Chromosome: 15
Canonical length: 304 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal complex disassembly. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q9NVM6|DNAJC17
     1  MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA ELFHQLSQAL
    61  EVLTDAAARA AYDKVRKAKK QAAERTQKLD EKRKKVKLDL EARERQAQAQ ESEEEEESRS
   121  TRTLEQEIER LREEGSRQLE EQQRLIREQI RQERDQRLRG KAENTEGQGT PKLKLKWKCK
   181  KEDESKGGYS KDVLLRLLQK YGEVLNLVLS SKKPGTAVVE FATVKAAELA VQNEVGLVDN
   241  PLKISWLEGQ PQDAVGRSHS GLSKGSVLSE RDYESLVMMR MRQAAERQQL IARMQQEDQE
   301  GPPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

ovary: 19 nTPM
parathyroid gland: 16 nTPM
tonsil: 16 nTPM
thymus: 15 nTPM
cerebellum: 14 nTPM
liver: 14 nTPM

Single-cell type

esophageal apical cells: 102 nCPM
prostatic club cells: 83 nCPM
lacrimal acinar cells: 79 nCPM
submucosal glandular cells: 71 nCPM
respiratory secretory cells: 62 nCPM
myonuclei: 60 nCPM

Immune cell

T-reg: 39 nTPM
basophil: 31 nTPM
eosinophil: 29 nTPM
intermediate monocyte: 29 nTPM
gdT-cell: 25 nTPM
myeloid DC: 24 nTPM

Brain region

cerebellum: 14 nTPM
cerebral cortex: 11 nTPM
amygdala: 8.8 nTPM
white matter: 8.7 nTPM
basal ganglia: 8.4 nTPM
thalamus: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -1.18
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA recognition motif domain
DnaJ domain
Nucleotide-binding alpha-beta plait domain superfamily
RNA-binding domain superfamily
Chaperone J-domain superfamily
RNA recognition motif
DnaJ domain
DNAJC17, RNA recognition motif
Pre-mRNA-splicing and ERAD-associated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC17 as an antibody target. Whether an autoantibody or antibody against DNAJC17 could matter depends on whether native DNAJC17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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