IGF2BP2

Protein identityUniProt · HPA

UniProt accession

Q9Y6M1

Gene

IGF2BP2

Ensembl

ENSG00000073792

Chromosome

3

Canonical length

599 aa

Protein class

Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homooligomer

OverviewNCBI Gene

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

599 residues, UniProt reviewed canonical sequence.

>Q9Y6M1|IGF2BP2
     1  MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG
    61  KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG LLAQYGTVEN VEQVNTDTET
   121  AVVNVTYATR EEAKIAMEKL SGHQFENYSF KISYIPDEEV SSPSPPQRAQ RGDHSSREQG
   181  HAPGGTSQAR QIDFPLRILV PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK
   241  PVTIHATPEG TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI
   301  EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE NDMLAVNQQA
   361  NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT THSGYFSSLY PHHQFGPFPH
   421  HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI KQLARFAGAS IKIAPAEGPD VSERMVIITG
   481  PPEAQFKAQG RIFGKLKEEN FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS
   541  AEVIVPRDQT PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGF2BP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

21 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGF2BP2.

Disease | ImmuneIEDB

Conditions an epitope on IGF2BP2 was assayed in.

• melanoma T cell
• chronic lymphocytic leukemia T cell
• skin melanoma T cell
• acute myeloid leukemia T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against IGF2BP2 are reported. Each links to that disease's full target list.

• Arthritis, Rheumatoid 5
• Liver Cirrhosis, Biliary 5
• Liver Neoplasms 3

Showing 3 of 4 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for IGF2BP2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.43

gnomAD pLI

0.24

gnomAD missense Z

2.91

DepMap mean gene effect

-0.24

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anatomical structure morphogenesis
• cold-induced thermogenesis
• CRD-mediated mRNA stabilization
• energy homeostasis
• mRNA transport
• negative regulation of translation
• nervous system development
• regulation of cytokine production
• RNA stabilization

Molecular functions

• mRNA 3'-UTR binding
• mRNA 5'-UTR binding
• N6-methyladenosine-containing RNA reader activity
• RNA binding
• translation regulator activity

Cellular components

• cytoplasm
• cytoplasmic stress granule
• cytoskeleton
• cytosol
• nucleus
• P-body

Protein domainsUniProt · Pfam · InterPro

• RNA recognition motif domain
• K Homology domain
• K Homology domain, type 1
• Nucleotide-binding alpha-beta plait domain superfamily
• RNA-binding domain superfamily
• K Homology domain, type 1 superfamily
• KH domain
• RNA recognition motif
• IGF2BP2, RNA recognition motif 1

KeywordsUniProt

• Acetylation
• Alternative initiation
• Cytoplasm
• mRNA transport
• Nucleus
• Phosphoprotein
• Repeat
• RNA-binding
• Translation regulation
• Transport

InteractionsUniProt · HPA

Protein binding partners of IGF2BP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DHX9
• ELAVL1
• HNRNPU
• HNRPD
• IGF2BP1
• MATR3
• PABPC1
• HNRNPD
• HOXB-AS3
• DYRK1A