Seroatlas · Human Serome Atlas

ZRSR2

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

Also known as: U2AF1-RS2, U2AF1L2, U2AFM_HUMAN, URP, ZC3H22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15696
Gene
ZRSR2
Ensembl
ENSG00000169249
Chromosome
X
Canonical length
482 aa
Protein class
Cancer-related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q15696|ZRSR2
     1  MAAPEKMTFP EKPSHKKYRA ALKKEKRKKR RQELARLRDS GLSQKEEEED TFIEEQQLEE
    61  EKLLERERQR LHEEWLLREQ KAQEEFRIKK EKEEAAKKRQ EEQERKLKEQ WEEQQRKERE
   121  EEEQKRQEKK EKEEALQKML DQAENELENG TTWQNPEPPV DFRVMEKDRA NCPFYSKTGA
   181  CRFGDRCSRK HNFPTSSPTL LIKSMFTTFG MEQCRRDDYD PDASLEYSEE ETYQQFLDFY
   241  EDVLPEFKNV GKVIQFKVSC NLEPHLRGNV YVQYQSEEEC QAALSLFNGR WYAGRQLQCE
   301  FCPVTRWKMA ICGLFEIQQC PRGKHCNFLH VFRNPNNEFW EANRDIYLSP DRTGSSFGKN
   361  SERRERMGHH DDYYSRLRGR RNPSPDHSYK RNGESERKSS RHRGKKSHKR TSKSRERHNS
   421  RSRGRNRDRS RDRSRGRGSR SRSRSRSRRS RRSRSQSSSR SRSRGRRRSG NRDRTVQSPK
   481  SK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZRSR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 38 nTPM
  • choroid plexus: 33 nTPM
  • spleen: 28 nTPM
  • lymph node: 25 nTPM
  • blood vessel: 25 nTPM
  • cerebellum: 22 nTPM

Single-cell type

  • cardiomyocytes: 182 nCPM
  • b-cells: 75 nCPM
  • cdc: 73 nCPM
  • tuft cells: 69 nCPM
  • thyrotrophs: 68 nCPM
  • myonuclei: 67 nCPM

Immune cell

  • naive B-cell: 33 nTPM
  • basophil: 32 nTPM
  • memory B-cell: 31 nTPM
  • naive CD4 T-cell: 23 nTPM
  • neutrophil: 23 nTPM
  • classical monocyte: 22 nTPM

Brain region

  • cerebellum: 20 nTPM
  • hypothalamus: 19 nTPM
  • choroid plexus: 18 nTPM
  • thalamus: 17 nTPM
  • amygdala: 17 nTPM
  • medulla oblongata: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZRSR2.

Disease | AllUniProt

Conditions ZRSR2 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 139 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
1.46
DepMap mean gene effect
-0.68
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZRSR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZRSR2 as an antibody target. Whether an autoantibody or antibody against ZRSR2 could matter depends on whether native ZRSR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZRSR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZRSR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZRSR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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