Seroatlas · Human Serome Atlas

RBM23

Probable RNA-binding protein 23

Also known as: CAPERbeta, FLJ10482, RBM23_HUMAN, RNPC4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86U06
Gene: RBM23
Ensembl: ENSG00000100461
Chromosome: 14
Canonical length: 439 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Intermediate filaments

OverviewNCBI Gene

This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q86U06|RBM23
     1  MASDDFDIVI EAMLEAPYKK EEDEQQRKEV KKDYPSNTTS STSNSGNETS GSSTIGETSK
    61  KKRSRSHNKS RDRKRSRSRD RDRYRRRNSR SRSPGRQCRH RSRSWDRRHG SESRSRDHRR
   121  EDRVHYRSPP LATGYRYGHS KSPHFREKSP VREPVDNLSP EERDARTVFC MQLAARIRPR
   181  DLEDFFSAVG KVRDVRIISD RNSRRSKGIA YVEFCEIQSV PLAIGLTGQR LLGVPIIVQA
   241  SQAEKNRLAA MANNLQKGNG GPMRLYVGSL HFNITEDMLR GIFEPFGKID NIVLMKDSDT
   301  GRSKGYGFIT FSDSECARRA LEQLNGFELA GRPMRVGHVT ERLDGGTDIT FPDGDQELDL
   361  GSAGGRFQLM AKLAEGAGIQ LPSTAAAAAA AAAQAAALQL NGAVPLGALN PAALTALSPA
   421  LNLASQCFQL SSLFTPQTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBM23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 78 nTPM
fallopian tube: 56 nTPM
thymus: 54 nTPM
ovary: 52 nTPM
thyroid gland: 51 nTPM
bone marrow: 50 nTPM

Single-cell type

neutrophils: 382 nCPM
rod photoreceptor cells: 169 nCPM
syncytiotrophoblasts: 168 nCPM
respiratory ciliated cells: 118 nCPM
ovarian stromal cells: 116 nCPM
fallopian tube ciliated cells: 108 nCPM

Immune cell

neutrophil: 137 nTPM
NK-cell: 60 nTPM
eosinophil: 51 nTPM
non-classical monocyte: 50 nTPM
myeloid DC: 50 nTPM
classical monocyte: 48 nTPM

Brain region

cerebellum: 92 nTPM
choroid plexus: 80 nTPM
white matter: 68 nTPM
hypothalamus: 67 nTPM
cerebral cortex: 58 nTPM
medulla oblongata: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBM23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBM23 as an antibody target. Whether an autoantibody or antibody against RBM23 could matter depends on whether native RBM23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBM23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBM23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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