Seroatlas · Human Serome Atlas

CSTF2

Cleavage stimulation factor subunit 2

Also known as: CstF-64, CSTF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P33240
Gene: CSTF2
Ensembl: ENSG00000101811
Chromosome: X
Canonical length: 577 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>P33240|CSTF2
     1  MAGLTVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD RETGKPKGYG
    61  FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGTGAPV IESPYGETIS
   121  PEDAPESISK AVASLPPEQM FELMKQMKLC VQNSPQEARN MLLQNPQLAY ALLQAQVVMR
   181  IVDPEIALKI LHRQTNIPTL IAGNPQPVHG AGPGSGSNVS MNQQNPQAPQ AQSLGGMHVN
   241  GAPPLMQASM QGGVPAPGQM PAAVTGPGPG SLAPGGGMQA QVGMPGSGPV SMERGQVPMQ
   301  DPRAAMQRGS LPANVPTPRG LLGDAPNDPR GGTLLSVTGE VEPRGYLGPP HQGPPMHHVP
   361  GHESRGPPPH ELRGGPLPEP RPLMAEPRGP MLDQRGPPLD GRGGRDPRGI DARGMEARAM
   421  EARGLDARGL EARAMEARAM EARAMEARAM EARAMEVRGM EARGMDTRGP VPGPRGPIPS
   481  GMQGPSPINM GAVVPQGSRQ VPVMQGTGMQ GASIQGGSQP GGFSPGQNQV TPQDHEKAAL
   541  IMQVLQLTAD QIAMLPPEQR QSILILKEQI QKSTGAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSTF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

tonsil: 18 nTPM
esophagus: 16 nTPM
rectum: 12 nTPM
testis: 11 nTPM
lymph node: 11 nTPM
thymus: 11 nTPM

Single-cell type

esophageal apical cells: 207 nCPM
esophageal suprabasal cells: 55 nCPM
early primary spermatocytes: 38 nCPM
megakaryocytes: 37 nCPM
oocytes: 37 nCPM
differentiating spermatogonia: 35 nCPM

Immune cell

non-classical monocyte: 27 nTPM
NK-cell: 24 nTPM
gdT-cell: 23 nTPM
myeloid DC: 22 nTPM
T-reg: 22 nTPM
memory CD8 T-cell: 21 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 13 nTPM
white matter: 13 nTPM
thalamus: 12 nTPM
basal ganglia: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSTF2.

Disease | AllUniProt

Conditions CSTF2 is implicated in, by any mechanism.

Intellectual developmental disorder, X-linked 113 (XLID113) MIM:301116

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 114 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder, X-linked 113

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 3.43
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSTF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSTF2 as an antibody target. Whether an autoantibody or antibody against CSTF2 could matter depends on whether native CSTF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSTF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSTF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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