Seroatlas · Human Serome Atlas

PABPN1L

Embryonic polyadenylate-binding protein 2

Also known as: EPAB2_HUMAN, ePABP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDY0
Gene: PABPN1L
Ensembl: ENSG00000205022
Chromosome: 16
Canonical length: 278 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable poly(A) binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to act upstream of or within maternal-to-zygotic transition of gene expression; negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process; and negative regulation of protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>A6NDY0|PABPN1L
     1  MWPFPSRSLF PPPTQAWLQT VSSDPEAQGW GAWNETKEIL GPEGGEGKEE KEEEEDAEED
    61  QDGDAGFLLS LLEQENLAEC PLPDQELEAI KMKVCAMEQA EGTPRPPGVQ QQAEEEEGTA
   121  AGQLLSPETV GCPLSGTPEE KVEADHRSVY VGNVDYGGSA EELEAHFSRC GEVHRVTILC
   181  DKFSGHPKGY AYIEFATKGS VQAAVELDQS LFRGRVIKVL PKRTNFPGIS STDRGGLRGH
   241  PGSRGAPFPH SGLQGRPRLR PQGQNRARGK FSPWFSPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABPN1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 2.4 nTPM
adrenal gland: 2.2 nTPM
bone marrow: 0.6 nTPM
basal ganglia: 0.5 nTPM
spleen: 0.5 nTPM
pancreas: 0.4 nTPM

Single-cell type

oocytes: 60 nCPM
adrenal cortex cells: 1.7 nCPM
hematopoietic stem cells: 1 nCPM
granulosa cells: 0.8 nCPM
pdcs: 0.6 nCPM
retinal bipolar cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.4 nTPM
cerebral cortex: 1.4 nTPM
basal ganglia: 1.1 nTPM
pons: 1 nTPM
white matter: 1 nTPM
amygdala: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.84
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

poly(A) binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PABPN1L as an antibody target. Whether an autoantibody or antibody against PABPN1L could matter depends on whether native PABPN1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PABPN1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PABPN1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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